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Items: 1 to 20 of 44


Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.


The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design.

Oosterveer MH, Grefhorst A, Groen AK, Kuipers F.

Prog Lipid Res. 2010 Oct;49(4):343-52. doi: 10.1016/j.plipres.2010.03.002. Epub 2010 Apr 2. Review.


Recent advances in nonalcoholic fatty liver disease.

Cheung O, Sanyal AJ.

Curr Opin Gastroenterol. 2010 May;26(3):202-8. doi: 10.1097/MOG.0b013e328337b0c4. Review.


mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

Laplante M, Sabatini DM.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3281-2. doi: 10.1073/pnas.1000323107. Epub 2010 Feb 18. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7617.


Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.

Li S, Brown MS, Goldstein JL.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6. doi: 10.1073/pnas.0914798107. Epub 2010 Feb 1.


Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.

Chanda D, Li T, Song KH, Kim YH, Sim J, Lee CH, Chiang JY, Choi HS.

J Biol Chem. 2009 Oct 16;284(42):28510-21. doi: 10.1074/jbc.M109.022244. Epub 2009 Aug 31.


DNA-PK: relaying the insulin signal to USF in lipogenesis.

Wong RH, Sul HS.

Cell Cycle. 2009 Jul 1;8(13):1977-8. Epub 2009 Jul 15. No abstract available.


Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Vander Heiden MG, Cantley LC, Thompson CB.

Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809. Review.


A role of DNA-PK for the metabolic gene regulation in response to insulin.

Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS.

Cell. 2009 Mar 20;136(6):1056-72. doi: 10.1016/j.cell.2008.12.040.


Biological role of liver X receptors.

Baranowski M.

J Physiol Pharmacol. 2008 Dec;59 Suppl 7:31-55. Review.


The role of the lipogenic pathway in the development of hepatic steatosis.

Postic C, Girard J.

Diabetes Metab. 2008 Dec;34(6 Pt 2):643-8. doi: 10.1016/S1262-3636(08)74599-3. Review.


Brain lipogenesis and regulation of energy metabolism.

López M, Vidal-Puig A.

Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):483-90. doi: 10.1097/MCO.0b013e328302f3d8. Review.


ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver.

Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, Postic C.

J Clin Invest. 2008 Mar;118(3):956-64. doi: 10.1172/JCI34314.


A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction.

Liu H, Liu Y, Zhang JT.

Mol Cancer Ther. 2008 Feb;7(2):263-70. doi: 10.1158/1535-7163.MCT-07-0445.


The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor.

Herzog B, Hallberg M, Seth A, Woods A, White R, Parker MG.

Mol Endocrinol. 2007 Nov;21(11):2687-97. Epub 2007 Aug 7.


ChREBP, a transcriptional regulator of glucose and lipid metabolism.

Postic C, Dentin R, Denechaud PD, Girard J.

Annu Rev Nutr. 2007;27:179-92. Review.


Sweet dreams for LXR.

Lazar MA, Willson TM.

Cell Metab. 2007 Mar;5(3):159-61.


Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.

Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N.

J Biol Chem. 2007 Apr 20;282(16):11687-95. Epub 2007 Feb 12.


Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter.

Griffin MJ, Wong RH, Pandya N, Sul HS.

J Biol Chem. 2007 Feb 23;282(8):5453-67. Epub 2006 Dec 31.


The nuclear receptor LXR is a glucose sensor.

Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E.

Nature. 2007 Jan 11;445(7124):219-23. Epub 2006 Dec 24.


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