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Items: 1 to 20 of 64

1.

Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha.

Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR.

Bioorg Med Chem. 2010 Feb;18(3):1103-10. doi: 10.1016/j.bmc.2009.12.056. Epub 2010 Jan 4.

2.

Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane.

Ng Y, Ramm G, Burchfield JG, Coster AC, Stöckli J, James DE.

J Biol Chem. 2010 Jan 22;285(4):2245-57. doi: 10.1074/jbc.M109.060236. Epub 2009 Nov 6.

3.

Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression, and putative role of a 16-kDa gamma(c) isoform.

Seelan RS, Lakshmanan J, Casanova MF, Parthasarathy RN.

J Biol Chem. 2009 Apr 3;284(14):9443-57. doi: 10.1074/jbc.M900206200. Epub 2009 Feb 2.

4.

A complex interplay between Akt, TSC2 and the two mTOR complexes.

Huang J, Manning BD.

Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22. doi: 10.1042/BST0370217. Review.

5.

Reciprocal control of pyruvate dehydrogenase kinase and phosphatase by inositol phosphoglycans. Dynamic state set by "push-pull" system.

McLean P, Kunjara S, Greenbaum AL, Gumaa K, López-Prados J, Martin-Lomas M, Rademacher TW.

J Biol Chem. 2008 Nov 28;283(48):33428-36. doi: 10.1074/jbc.M801781200. Epub 2008 Sep 3.

8.

Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome.

Baillargeon JP, Diamanti-Kandarakis E, Ostlund RE Jr, Apridonidze T, Iuorno MJ, Nestler JE.

Diabetes Care. 2006 Feb;29(2):300-5.

PMID:
16443877
9.

Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2.

Scioscia M, Gumaa K, Kunjara S, Paine MA, Selvaggi LE, Rodeck CH, Rademacher TW.

J Clin Endocrinol Metab. 2006 Feb;91(2):709-17. Epub 2005 Dec 6.

PMID:
16332940
10.

Determination of urinary Myo-/chiro-inositol ratios from Korean diabetes patients.

Jung TS, Hahm JR, Kim JJ, Jung JH, Kang MY, Moon SW, Lee KW, Kim HC, Lee JD, Kim JH, Kim DR, Chung SI.

Yonsei Med J. 2005 Aug 31;46(4):532-8.

11.

An anionic inositol phosphate glycan pseudotetrasaccharide exhibits high insulin-mimetic activity in rat adipocytes.

Chakraborty N, d'Alarcao M.

Bioorg Med Chem. 2005 Dec 15;13(24):6732-41. Epub 2005 Aug 22.

PMID:
16115771
12.

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

Brautigan DL, Brown M, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal M, Keller S, Tamura S, Heimark DB, Price J, Larner AN, Larner J.

Biochemistry. 2005 Aug 23;44(33):11067-73. Erratum in: Biochemistry. 2005 Nov 22;44(46):15422.

PMID:
16101290
13.

Origins and evolution of the Western diet: health implications for the 21st century.

Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J.

Am J Clin Nutr. 2005 Feb;81(2):341-54. Review.

14.

Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins.

Samari HR, Møller MT, Holden L, Asmyhr T, Seglen PO.

Biochem J. 2005 Mar 1;386(Pt 2):237-44.

15.

Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.

Yoshizaki T, Maegawa H, Egawa K, Ugi S, Nishio Y, Imamura T, Kobayashi T, Tamura S, Olefsky JM, Kashiwagi A.

J Biol Chem. 2004 May 21;279(21):22715-26. Epub 2004 Mar 11.

16.

Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome.

Baillargeon JP, Iuorno MJ, Jakubowicz DJ, Apridonidze T, He N, Nestler JE.

J Clin Endocrinol Metab. 2004 Jan;89(1):242-9.

PMID:
14715857
17.

Manganese-induced hypoglycaemia.

RUBENSTEIN AH, LEVIN NW, ELLIOTT GA.

Lancet. 1962 Dec 29;2(7270):1348-51. No abstract available.

PMID:
13982963
18.

The renal excretion of inositol in normal and diabetic human beings.

DAUGHADAY WH, LARNER J.

J Clin Invest. 1954 Mar;33(3):326-32. No abstract available.

19.

Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity.

Larner J, Price JD, Heimark D, Smith L, Rule G, Piccariello T, Fonteles MC, Pontes C, Vale D, Huang L.

J Med Chem. 2003 Jul 17;46(15):3283-91.

PMID:
12852758
20.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Inoki K, Li Y, Zhu T, Wu J, Guan KL.

Nat Cell Biol. 2002 Sep;4(9):648-57.

PMID:
12172553

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