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Feedback between p21 and reactive oxygen production is necessary for cell senescence.

Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T.

Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16.


Traditional anthropometric parameters still predict metabolic disorders in women with severe obesity.

Ledoux S, Coupaye M, Essig M, Msika S, Roy C, Queguiner I, Clerici C, Larger E.

Obesity (Silver Spring). 2010 May;18(5):1026-32. doi: 10.1038/oby.2009.349. Epub 2009 Oct 22.


Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue.

Rutkowski JM, Davis KE, Scherer PE.

FEBS J. 2009 Oct;276(20):5738-46. doi: 10.1111/j.1742-4658.2009.07303.x. Epub 2009 Sep 15. Review.


A crucial role for adipose tissue p53 in the regulation of insulin resistance.

Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I.

Nat Med. 2009 Sep;15(9):1082-7. doi: 10.1038/nm.2014. Epub 2009 Aug 30.


Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators.

Duffaut C, Zakaroff-Girard A, Bourlier V, Decaunes P, Maumus M, Chiotasso P, Sengenès C, Lafontan M, Galitzky J, Bouloumié A.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1608-14. doi: 10.1161/ATVBAHA.109.192583. Epub 2009 Jul 30.


The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects.

Ortega FJ, Mayas D, Moreno-Navarrete JM, Catalán V, Gómez-Ambrosi J, Esteve E, Rodriguez-Hermosa JI, Ruiz B, Ricart W, Peral B, Fruhbeck G, Tinahones FJ, Fernández-Real JM.

Obesity (Silver Spring). 2010 Jan;18(1):13-20. doi: 10.1038/oby.2009.202. Epub 2009 Jun 18.


Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.

Wang CY, Kim HH, Hiroi Y, Sawada N, Salomone S, Benjamin LE, Walsh K, Moskowitz MA, Liao JK.

Sci Signal. 2009 Mar 17;2(62):ra11. doi: 10.1126/scisignal.2000143.


PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice.

Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J.

J Clin Invest. 2009 Jan;119(1):110-24. doi: 10.1172/JCI36233. Epub 2008 Dec 8.


Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J.

PLoS Biol. 2008 Dec 2;6(12):2853-68. doi: 10.1371/journal.pbio.0060301.


Vascular endothelial senescence: from mechanisms to pathophysiology.

Erusalimsky JD.

J Appl Physiol (1985). 2009 Jan;106(1):326-32. doi: 10.1152/japplphysiol.91353.2008. Epub 2008 Nov 26. Review.


Role of body fat distribution and the metabolic complications of obesity.

Jensen MD.

J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S57-63. doi: 10.1210/jc.2008-1585. Review.


GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins.

Beigneux AP, Davies BS, Bensadoun A, Fong LG, Young SG.

J Lipid Res. 2009 Apr;50 Suppl:S57-62. doi: 10.1194/jlr.R800030-JLR200. Epub 2008 Oct 14. Review.


The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.

Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG.

Mol Endocrinol. 2008 Nov;22(11):2496-504. doi: 10.1210/me.2008-0146. Epub 2008 Sep 11. Erratum in: Mol Endocrinol. 2008 Dec;22(12):2766.


DNA double-strand breaks after percutaneous transluminal angioplasty.

Geisel D, Heverhagen JT, Kalinowski M, Wagner HJ.

Radiology. 2008 Sep;248(3):852-9. doi: 10.1148/radiol.2483071686.


Inflammation is associated with a decrease of lipogenic factors in omental fat in women.

Poulain-Godefroy O, Lecoeur C, Pattou F, Frühbeck G, Froguel P.

Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R1-7. doi: 10.1152/ajpregu.00926.2007. Epub 2008 Apr 30.


T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance.

Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TF, Dragun D, Skurk T, Hauner H, Blüher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1304-10. doi: 10.1161/ATVBAHA.108.165100. Epub 2008 Apr 17.


Sirt1 modulates premature senescence-like phenotype in human endothelial cells.

Ota H, Akishita M, Eto M, Iijima K, Kaneki M, Ouchi Y.

J Mol Cell Cardiol. 2007 Nov;43(5):571-9. Epub 2007 Aug 22.


Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes.

Wang B, Wood IS, Trayhurn P.

Pflugers Arch. 2007 Dec;455(3):479-92. Epub 2007 Jul 3.


Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.

Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG.

Cell Metab. 2007 Apr;5(4):279-91.

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