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Items: 1 to 20 of 62


Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern.

Hultman KA, Johnson SL.

Dev Biol. 2010 Jan 15;337(2):425-31. doi: 10.1016/j.ydbio.2009.11.019. Epub 2009 Nov 18.


Predicting new molecular targets for known drugs.

Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL.

Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506. Epub 2009 Nov 1.


Finding the missing heritability of complex diseases.

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM.

Nature. 2009 Oct 8;461(7265):747-53. doi: 10.1038/nature08494. Review.


Hitchhiking of Cu/Zn superoxide dismutase to peroxisomes--evidence for a natural piggyback import mechanism in mammals.

Islinger M, Li KW, Seitz J, Völkl A, Lüers GH.

Traffic. 2009 Nov;10(11):1711-21. doi: 10.1111/j.1600-0854.2009.00966.x. Epub 2009 Jul 21.


Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.

Tan CS, Bodenmiller B, Pasculescu A, Jovanovic M, Hengartner MO, Jørgensen C, Bader GD, Aebersold R, Pawson T, Linding R.

Sci Signal. 2009 Jul 28;2(81):ra39. doi: 10.1126/scisignal.2000316.


AP-3-dependent trafficking and disease: the first decade.

Dell'Angelica EC.

Curr Opin Cell Biol. 2009 Aug;21(4):552-9. doi: 10.1016/ Epub 2009 Jun 3. Review.


Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.

Anastasaki C, Estep AL, Marais R, Rauen KA, Patton EE.

Hum Mol Genet. 2009 Jul 15;18(14):2543-54. doi: 10.1093/hmg/ddp186. Epub 2009 Apr 17.


Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae.

Jo WJ, Kim JH, Oh E, Jaramillo D, Holman P, Loguinov AV, Arkin AP, Nislow C, Giaever G, Vulpe CD.

BMC Genomics. 2009 Mar 25;10:130. doi: 10.1186/1471-2164-10-130.


(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.

Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4519-24. doi: 10.1073/pnas.0900780106. Epub 2009 Feb 27.


Pb/Cu effects on the organization of microtubule cytoskeleton in interphase and mitotic cells of Allium sativum L.

Liu D, Xue P, Meng Q, Zou J, Gu J, Jiang W.

Plant Cell Rep. 2009 Apr;28(4):695-702. doi: 10.1007/s00299-009-0669-3. Epub 2009 Jan 16.


Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.

Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L, Boudreau M, Meloche C, Drouin R, Hudson TJ, Drapeau P, Cossette P.

PLoS Genet. 2008 Dec;4(12):e1000296. doi: 10.1371/journal.pgen.1000296. Epub 2008 Dec 5.


Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Yu L, Lopez A, Anaflous A, El Bali B, Hamal A, Ericson E, Heisler LE, McQuibban A, Giaever G, Nislow C, Boone C, Brown GW, Bellaoui M.

PLoS Genet. 2008 Nov;4(11):e1000284. doi: 10.1371/journal.pgen.1000284. Epub 2008 Nov 28.


Zebrafish mutants calamity and catastrophe define critical pathways of gene-nutrient interactions in developmental copper metabolism.

Madsen EC, Gitlin JD.

PLoS Genet. 2008 Nov;4(11):e1000261. doi: 10.1371/journal.pgen.1000261. Epub 2008 Nov 14.


Chemical biology and the limits of reductionism.

Peterson RT.

Nat Chem Biol. 2008 Nov;4(11):635-8. doi: 10.1038/nchembio1108-635. No abstract available.


Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks.

Zilberman D, Coleman-Derr D, Ballinger T, Henikoff S.

Nature. 2008 Nov 6;456(7218):125-9. doi: 10.1038/nature07324. Epub 2008 Sep 24.


Expression of copper-related genes in response to copper load.

González M, Reyes-Jara A, Suazo M, Jo WJ, Vulpe C.

Am J Clin Nutr. 2008 Sep;88(3):830S-4S.


Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

Ericson E, Gebbia M, Heisler LE, Wildenhain J, Tyers M, Giaever G, Nislow C.

PLoS Genet. 2008 Aug 8;4(8):e1000151. doi: 10.1371/journal.pgen.1000151.


Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes.

Setty SR, Tenza D, Sviderskaya EV, Bennett DC, Raposo G, Marks MS.

Nature. 2008 Aug 28;454(7208):1142-6. doi: 10.1038/nature07163. Epub 2008 Jul 23.


Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway.

Sebolt-Leopold JS.

Clin Cancer Res. 2008 Jun 15;14(12):3651-6. doi: 10.1158/1078-0432.CCR-08-0333.


The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism.

Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, Hofmann K, Thumm M, Wolf DH.

Mol Biol Cell. 2008 Aug;19(8):3323-33. doi: 10.1091/mbc.E08-03-0328. Epub 2008 May 28.

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