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Apparent activity in high-throughput screening: origins of compound-dependent assay interference.

Thorne N, Auld DS, Inglese J.

Curr Opin Chem Biol. 2010 Jun;14(3):315-24. doi: 10.1016/j.cbpa.2010.03.020. Review.


HTS-compatible beta-lactamase transcriptional reporter gene assay for interrogating the heat shock response pathway.

Hancock MK, Xia M, Frey ES, Sakamuru S, Bi K.

Curr Chem Genomics. 2009 Feb 5;3:1-6. doi: 10.2174/1875397300903010001.


Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action.

Miller SC, Huang R, Sakamuru S, Shukla SJ, Attene-Ramos MS, Shinn P, Van Leer D, Leister W, Austin CP, Xia M.

Biochem Pharmacol. 2010 May 1;79(9):1272-80. doi: 10.1016/j.bcp.2009.12.021.


Comparison of bioluminescent kinase assays using substrate depletion and product formation.

Tanega C, Shen M, Mott BT, Thomas CJ, MacArthur R, Inglese J, Auld DS.

Assay Drug Dev Technol. 2009 Dec;7(6):606-14. doi: 10.1089/adt.2009.0230.


Identification of small molecule compounds that inhibit the HIF-1 signaling pathway.

Xia M, Bi K, Huang R, Cho MH, Sakamuru S, Miller SC, Li H, Sun Y, Printen J, Austin CP, Inglese J.

Mol Cancer. 2009 Dec 9;8:117. doi: 10.1186/1476-4598-8-117.


The pilot phase of the NIH Chemical Genomics Center.

Thomas CJ, Auld DS, Huang R, Huang W, Jadhav A, Johnson RL, Leister W, Maloney DJ, Marugan JJ, Michael S, Simeonov A, Southall N, Xia M, Zheng W, Inglese J, Austin CP.

Curr Top Med Chem. 2009;9(13):1181-93. Review.


Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features.

Huang R, Southall N, Xia M, Cho MH, Jadhav A, Nguyen DT, Inglese J, Tice RR, Austin CP.

Toxicol Sci. 2009 Dec;112(2):385-93. doi: 10.1093/toxsci/kfp231.


Automated high-content screening for compounds that disassemble the perinucleolar compartment.

Norton JT, Titus SA, Dexter D, Austin CP, Zheng W, Huang S.

J Biomol Screen. 2009 Oct;14(9):1045-53. doi: 10.1177/1087057109343120.


Hypoxia response: a model toxicity pathway for high-throughput screening.

Simmons SO.

Toxicol Sci. 2009 Nov;112(1):1-3. doi: 10.1093/toxsci/kfp193. No abstract available.


TOX 21: new dimensions of toxicity testing.

Schmidt CW.

Environ Health Perspect. 2009 Aug;117(8):A348-53. No abstract available.


A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries.

Johnson RL, Huang R, Jadhav A, Southall N, Wichterman J, MacArthur R, Xia M, Bi K, Printen J, Austin CP, Inglese J.

Mol Biosyst. 2009 Sep;5(9):1039-50. doi: 10.1039/b902021g.


A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W.

Anal Biochem. 2009 Nov 1;394(1):30-8. doi: 10.1016/j.ab.2009.07.003.


Cellular stress response pathway system as a sentinel ensemble in toxicological screening.

Simmons SO, Fan CY, Ramabhadran R.

Toxicol Sci. 2009 Oct;111(2):202-25. doi: 10.1093/toxsci/kfp140. Review.


A dual-fluorescence high-throughput cell line system for probing multidrug resistance.

Brimacombe KR, Hall MD, Auld DS, Inglese J, Austin CP, Gottesman MM, Fung KL.

Assay Drug Dev Technol. 2009 Jun;7(3):233-49. doi: 10.1089/adt.2008.165.


Bringing toxicology into the 21st century: a global call to action.

Seidle T, Stephens ML.

Toxicol In Vitro. 2009 Dec;23(8):1576-9. doi: 10.1016/j.tiv.2009.06.012.


Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.

Shukla SJ, Nguyen DT, Macarthur R, Simeonov A, Frazee WJ, Hallis TM, Marks BD, Singh U, Eliason HC, Printen J, Austin CP, Inglese J, Auld DS.

Assay Drug Dev Technol. 2009 Apr;7(2):143-69. doi: 10.1089/adt.2009.193.


Identification of chemical compounds that induce HIF-1alpha activity.

Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP.

Toxicol Sci. 2009 Nov;112(1):153-63. doi: 10.1093/toxsci/kfp123.


Monitoring compound integrity with cytochrome P450 assays and qHTS.

MacArthur R, Leister W, Veith H, Shinn P, Southall N, Austin CP, Inglese J, Auld DS.

J Biomol Screen. 2009 Jun;14(5):538-46. doi: 10.1177/1087057109336954.


The toxicity data landscape for environmental chemicals.

Judson R, Richard A, Dix DJ, Houck K, Martin M, Kavlock R, Dellarco V, Henry T, Holderman T, Sayre P, Tan S, Carpenter T, Smith E.

Environ Health Perspect. 2009 May;117(5):685-95. doi: 10.1289/ehp.0800168. Review.


Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory.

Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7. doi: 10.1073/pnas.0813020106.

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