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Items: 1 to 20 of 35

1.

Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity.

Desai R, Ruesch D, Forman SA.

Anesthesiology. 2009 Oct;111(4):774-84. doi: 10.1097/ALN.0b013e3181b55fae.

2.

Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation.

Stewart D, Desai R, Cheng Q, Liu A, Forman SA.

Mol Pharmacol. 2008 Dec;74(6):1687-95. doi: 10.1124/mol.108.050500. Epub 2008 Sep 19.

3.

Ecotoxicology of narcosis: stereoselectivity and potential target sites.

Sandermann H.

Chemosphere. 2008 Jul;72(9):1256-9. doi: 10.1016/j.chemosphere.2008.05.002. Epub 2008 Jun 17.

PMID:
18561982
4.

Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector.

Nirthanan S, Garcia G 3rd, Chiara DC, Husain SS, Cohen JB.

J Biol Chem. 2008 Aug 8;283(32):22051-62. doi: 10.1074/jbc.M801332200. Epub 2008 Jun 4.

5.

New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.

Zolle IM, Berger ML, Hammerschmidt F, Hahner S, Schirbel A, Peric-Simov B.

J Med Chem. 2008 Apr 10;51(7):2244-53. doi: 10.1021/jm800012w. Epub 2008 Mar 19. Erratum in: J Med Chem. 2008 Dec 11;51(23):7652.

PMID:
18348518
6.

The synthesis of 5-imidazolecarboxylates from glycine and substituted glycine esters.

JONES RG.

J Am Chem Soc. 1949 Feb;71(2):644-7. No abstract available.

PMID:
18112072
7.

Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel.

Bright DP, Adham SD, Lemaire LC, Benavides R, Gruss M, Taylor GW, Smith EH, Franks NP.

J Biol Chem. 2007 Apr 20;282(16):12038-47. Epub 2007 Feb 20.

8.

Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment.

Rosen A, Bali M, Horenstein J, Akabas MH.

Biophys J. 2007 May 1;92(9):3130-9. Epub 2007 Feb 9.

9.

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

Li GD, Chiara DC, Sawyer GW, Husain SS, Olsen RW, Cohen JB.

J Neurosci. 2006 Nov 8;26(45):11599-605.

10.

Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.

Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW.

J Med Chem. 2006 Aug 10;49(16):4818-25.

PMID:
16884293
11.

General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition.

Solt K, Stevens RJ, Davies PA, Raines DE.

J Pharmacol Exp Ther. 2005 Nov;315(2):771-6. Epub 2005 Aug 4.

13.

Molecular and neuronal substrates for general anaesthetics.

Rudolph U, Antkowiak B.

Nat Rev Neurosci. 2004 Sep;5(9):709-20. Review.

PMID:
15322529
14.
15.

Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic.

Ziebell MR, Nirthanan S, Husain SS, Miller KW, Cohen JB.

J Biol Chem. 2004 Apr 23;279(17):17640-9. Epub 2004 Feb 3.

16.

Defining the propofol binding site location on the GABAA receptor.

Bali M, Akabas MH.

Mol Pharmacol. 2004 Jan;65(1):68-76.

17.

DL-1-(1-ARYLALKYL)IMIDAZOLE-5-CARBOXYLATE ESTERS. A NOVEL TYPE OF HYPNOTIC AGENTS.

GODEFROI EF, JANSSEN PA, VANDEREYCKEN CA, VANHEERTUM AH, NIEMEGEERS CJ.

J Med Chem. 1965 Mar;8:220-3. No abstract available.

PMID:
14332665
18.

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, Lambert JJ, Dawson GR, McKernan R, Whiting PJ, Wafford KA.

J Neurosci. 2003 Sep 17;23(24):8608-17.

19.

2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels.

Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, Olsen RW, Forman SA, Cohen JB, Miller KW.

J Med Chem. 2003 Mar 27;46(7):1257-65.

PMID:
12646036
20.

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U.

FASEB J. 2003 Feb;17(2):250-2. Epub 2002 Dec 3.

PMID:
12475885

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