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Items: 1 to 20 of 49


The alphabeta T cell receptor is an anisotropic mechanosensor.

Kim ST, Takeuchi K, Sun ZY, Touma M, Castro CE, Fahmy A, Lang MJ, Wagner G, Reinherz EL.

J Biol Chem. 2009 Nov 6;284(45):31028-37. doi: 10.1074/jbc.M109.052712. Epub 2009 Sep 15.


Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J.

Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21.


T cell activation.

Smith-Garvin JE, Koretzky GA, Jordan MS.

Annu Rev Immunol. 2009;27:591-619. doi: 10.1146/annurev.immunol.021908.132706. Review.


Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.

Ma Z, Sharp KA, Janmey PA, Finkel TH.

PLoS Biol. 2008 Feb;6(2):e43. doi: 10.1371/journal.pbio.0060043.


Common themes in the assembly and architecture of activating immune receptors.

Call ME, Wucherpfennig KW.

Nat Rev Immunol. 2007 Nov;7(11):841-50. Review.


Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly.

Touma M, Sun ZY, Clayton LK, Marissen WE, Kruisbeek AM, Wagner G, Reinherz EL.

J Immunol. 2007 Mar 15;178(6):3668-79.


Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

Minguet S, Swamy M, Alarcón B, Luescher IF, Schamel WW.

Immunity. 2007 Jan;26(1):43-54. Epub 2006 Dec 21.


Overlapping functions of human CD3delta and mouse CD3gamma in alphabeta T-cell development revealed in a humanized CD3gamma-mouse.

Fernández-Malavé E, Wang N, Pulgar M, Schamel WW, Alarcón B, Terhorst C.

Blood. 2006 Nov 15;108(10):3420-7. Epub 2006 Aug 3.


The TCR C beta FG loop regulates alpha beta T cell development.

Touma M, Chang HC, Sasada T, Handley M, Clayton LK, Reinherz EL.

J Immunol. 2006 Jun 1;176(11):6812-23.


T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.

Alarcón B, Swamy M, van Santen HM, Schamel WW.

EMBO Rep. 2006 May;7(5):490-5. Review.


How TCRs bind MHCs, peptides, and coreceptors.

Rudolph MG, Stanfield RL, Wilson IA.

Annu Rev Immunol. 2006;24:419-66. Review.


The evolution of adaptive immune systems.

Cooper MD, Alder MN.

Cell. 2006 Feb 24;124(4):815-22. Review.


T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA.

Nature. 2005 Jul 28;436(7050):578-82.


TCR signal strength influences alphabeta/gammadelta lineage fate.

Hayes SM, Li L, Love PE.

Immunity. 2005 May;22(5):583-93.


Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.

Adams EJ, Chien YH, Garcia KC.

Science. 2005 Apr 8;308(5719):227-31.


Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.

Sun ZY, Kim ST, Kim IC, Fahmy A, Reinherz EL, Wagner G.

Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16867-72. Epub 2004 Nov 19.


Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

Arnett KL, Harrison SC, Wiley DC.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16268-73. Epub 2004 Nov 8.


Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10.


An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors.

Hayes SM, Shores EW, Love PE.

Immunol Rev. 2003 Feb;191:28-37. Review.


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