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Items: 1 to 20 of 31

1.

alpha7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma?

Paleari L, Cesario A, Fini M, Russo P.

Drug Discov Today. 2009 Sep;14(17-18):822-36. doi: 10.1016/j.drudis.2009.06.016. Epub 2009 Jul 16. Review.

PMID:
19616116
2.

Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists.

López-Hernández GY, Thinschmidt JS, Zheng G, Zhang Z, Crooks PA, Dwoskin LP, Papke RL.

Mol Pharmacol. 2009 Sep;76(3):652-66. doi: 10.1124/mol.109.056176. Epub 2009 Jun 25.

3.

Conformational sampling of druglike molecules with MOE and catalyst: implications for pharmacophore modeling and virtual screening.

Chen IJ, Foloppe N.

J Chem Inf Model. 2008 Sep;48(9):1773-91. doi: 10.1021/ci800130k. Epub 2008 Sep 3.

PMID:
18763758
4.

Neuronal nicotinic receptors: a perspective on two decades of drug discovery research.

Arneric SP, Holladay M, Williams M.

Biochem Pharmacol. 2007 Oct 15;74(8):1092-101. Epub 2007 Jun 26. Review.

PMID:
17662959
5.

The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents.

Boess FG, De Vry J, Erb C, Flessner T, Hendrix M, Luithle J, Methfessel C, Riedl B, Schnizler K, van der Staay FJ, van Kampen M, Wiese WB, Koenig G.

J Pharmacol Exp Ther. 2007 May;321(2):716-25. Epub 2007 Feb 16.

6.

Selective alpha7 nicotinic acetylcholine receptor ligands.

Mazurov A, Hauser T, Miller CH.

Curr Med Chem. 2006;13(13):1567-84. Review. Erratum in: Curr Med Chem. 2007;14(14):1593.

PMID:
16787204
7.

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia.

Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R.

Arch Gen Psychiatry. 2006 Jun;63(6):630-8.

PMID:
16754836
8.

Strategies for compound selection.

Olah MM, Bologa CG, Oprea TI.

Curr Drug Discov Technol. 2004 Oct;1(3):211-20. Review.

PMID:
16472248
9.

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Jensen AA, Frølund B, Liljefors T, Krogsgaard-Larsen P.

J Med Chem. 2005 Jul 28;48(15):4705-45. Review. No abstract available.

PMID:
16033252
10.

Nicotinic antagonists in the treatment of nerve agent intoxication.

Sheridan RD, Smith AP, Turner SR, Tattersall JE.

J R Soc Med. 2005 Mar;98(3):114-5. Review. No abstract available.

11.

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

Bodnar AL, Cortes-Burgos LA, Cook KK, Dinh DM, Groppi VE, Hajos M, Higdon NR, Hoffmann WE, Hurst RS, Myers JK, Rogers BN, Wall TM, Wolfe ML, Wong E.

J Med Chem. 2005 Feb 24;48(4):905-8.

PMID:
15715459
12.

Nicotinic receptors and schizophrenia.

Ripoll N, Bronnec M, Bourin M.

Curr Med Res Opin. 2004 Jul;20(7):1057-74. Review.

PMID:
15265251
13.

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

Celie PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB, Sixma TK.

Neuron. 2004 Mar 25;41(6):907-14.

14.

Nicotine and nicotinic receptor involvement in neuropsychiatric disorders.

Newhouse P, Singh A, Potter A.

Curr Top Med Chem. 2004;4(3):267-82. Review.

PMID:
14754447
15.

Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands.

Astles PC, Baker SR, Boot JR, Broad LM, Dell CP, Keenan M.

Curr Drug Targets CNS Neurol Disord. 2002 Aug;1(4):337-48. Review.

PMID:
12769608
16.

PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor.

Broad LM, Felthouse C, Zwart R, McPhie GI, Pearson KH, Craig PJ, Wallace L, Broadmore RJ, Boot JR, Keenan M, Baker SR, Sher E.

Eur J Pharmacol. 2002 Oct 4;452(2):137-44.

PMID:
12354563
17.

Nicotinic acetylcholine receptors as targets for antidepressants.

Shytle RD, Silver AA, Lukas RJ, Newman MB, Sheehan DV, Sanberg PR.

Mol Psychiatry. 2002;7(6):525-35. Review.

18.

Neuronal nicotinic receptors in the human brain.

Paterson D, Nordberg A.

Prog Neurobiol. 2000 May;61(1):75-111. Review.

PMID:
10759066
19.

Property distribution of drug-related chemical databases.

Oprea TI.

J Comput Aided Mol Des. 2000 Mar;14(3):251-64.

PMID:
10756480
20.

Looking back on the discovery of alpha-bungarotoxin.

Chang CC.

J Biomed Sci. 1999 Nov-Dec;6(6):368-75.

PMID:
10545772

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