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Items: 1 to 20 of 49

1.

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.

Sanz A, Soikkeli M, Portero-Otín M, Wilson A, Kemppainen E, McIlroy G, Ellilä S, Kemppainen KK, Tuomela T, Lakanmaa M, Kiviranta E, Stefanatos R, Dufour E, Hutz B, Naudí A, Jové M, Zeb A, Vartiainen S, Matsuno-Yagi A, Yagi T, Rustin P, Pamplona R, Jacobs HT.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9105-10. doi: 10.1073/pnas.0911539107. Epub 2010 Apr 30.

2.

Molecular gene therapy: overexpression of the alternative NADH dehydrogenase NDI1 restores overall physiology in a fungal model of respiratory complex I deficiency.

Maas MF, Sellem CH, Krause F, Dencher NA, Sainsard-Chanet A.

J Mol Biol. 2010 May 28;399(1):31-40. doi: 10.1016/j.jmb.2010.04.015. Epub 2010 Apr 14.

PMID:
20398675
3.

Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan.

Bahadorani S, Cho J, Lo T, Contreras H, Lawal HO, Krantz DE, Bradley TJ, Walker DW.

Aging Cell. 2010 Apr;9(2):191-202. doi: 10.1111/j.1474-9726.2010.00546.x.

4.

Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy.

Marella M, Seo BB, Yagi T, Matsuno-Yagi A.

J Bioenerg Biomembr. 2009 Dec;41(6):493-7. doi: 10.1007/s10863-009-9249-z. Review.

5.

Neuroprotective effect of long-term NDI1 gene expression in a chronic mouse model of Parkinson disorder.

Barber-Singh J, Seo BB, Nakamaru-Ogiso E, Lau YS, Matsuno-Yagi A, Yagi T.

Rejuvenation Res. 2009 Aug;12(4):259-67. doi: 10.1089/rej.2009.0854.

6.

Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year.

Cideciyan AV, Hauswirth WW, Aleman TS, Kaushal S, Schwartz SB, Boye SL, Windsor EA, Conlon TJ, Sumaroka A, Pang JJ, Roman AJ, Byrne BJ, Jacobson SG.

Hum Gene Ther. 2009 Sep;20(9):999-1004. doi: 10.1089/hum.2009.086.

7.

A critical approach to the therapy of mitochondrial respiratory chain and oxidative phosphorylation diseases.

Dimauro S, Rustin P.

Biochim Biophys Acta. 2009 Dec;1792(12):1159-67. doi: 10.1016/j.bbadis.2008.10.015. Epub 2008 Nov 5. Review.

8.

Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.

Ellouze S, Augustin S, Bouaita A, Bonnet C, Simonutti M, Forster V, Picaud S, Sahel JA, Corral-Debrinski M.

Am J Hum Genet. 2008 Sep;83(3):373-87. doi: 10.1016/j.ajhg.2008.08.013. Epub 2008 Sep 4.

9.

The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes.

Bonnet C, Augustin S, Ellouze S, Bénit P, Bouaita A, Rustin P, Sahel JA, Corral-Debrinski M.

Biochim Biophys Acta. 2008 Oct;1783(10):1707-17. doi: 10.1016/j.bbamcr.2008.04.018. Epub 2008 May 6.

10.

Effect of gene therapy on visual function in Leber's congenital amaurosis.

Bainbridge JW, Smith AJ, Barker SS, Robbie S, Henderson R, Balaggan K, Viswanathan A, Holder GE, Stockman A, Tyler N, Petersen-Jones S, Bhattacharya SS, Thrasher AJ, Fitzke FW, Carter BJ, Rubin GS, Moore AT, Ali RR.

N Engl J Med. 2008 May 22;358(21):2231-9. doi: 10.1056/NEJMoa0802268. Epub 2008 Apr 27.

11.

Safety and efficacy of gene transfer for Leber's congenital amaurosis.

Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, Sun J, Jacobs J, Dell'Osso L, Hertle R, Ma JX, Redmond TM, Zhu X, Hauck B, Zelenaia O, Shindler KS, Maguire MG, Wright JF, Volpe NJ, McDonnell JW, Auricchio A, High KA, Bennett J.

N Engl J Med. 2008 May 22;358(21):2240-8. doi: 10.1056/NEJMoa0802315. Epub 2008 Apr 27.

12.

Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease.

Marella M, Seo BB, Nakamaru-Ogiso E, Greenamyre JT, Matsuno-Yagi A, Yagi T.

PLoS One. 2008 Jan 16;3(1):e1433. doi: 10.1371/journal.pone.0001433.

13.

Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease.

DeCorby A, Gásková D, Sayles LC, Lemire BD.

Biochim Biophys Acta. 2007 Sep;1767(9):1157-63. Epub 2007 Jul 19.

14.

Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons.

Escobar-Khondiker M, Höllerhage M, Muriel MP, Champy P, Bach A, Depienne C, Respondek G, Yamada ES, Lannuzel A, Yagi T, Hirsch EC, Oertel WH, Jacob R, Michel PP, Ruberg M, Höglinger GU.

J Neurosci. 2007 Jul 18;27(29):7827-37.

15.

Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line.

Marella M, Seo BB, Matsuno-Yagi A, Yagi T.

J Biol Chem. 2007 Aug 17;282(33):24146-56. Epub 2007 Jun 20.

16.

Axonal loss and neuroprotection in optic neuropathies.

Levin LA.

Can J Ophthalmol. 2007 Jun;42(3):403-8. Review.

PMID:
17508035
18.

The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I.

Seo BB, Marella M, Yagi T, Matsuno-Yagi A.

FEBS Lett. 2006 Nov 13;580(26):6105-8. Epub 2006 Oct 16.

19.

Can a single subunit yeast NADH dehydrogenase (Ndi1) remedy diseases caused by respiratory complex I defects?

Yagi T, Seo BB, Nakamaru-Ogiso E, Marella M, Barber-Singh J, Yamashita T, Kao MC, Matsuno-Yagi A.

Rejuvenation Res. 2006 Summer;9(2):191-7.

PMID:
16706641
20.

Possibility of transkingdom gene therapy for complex I diseases.

Yagi T, Seo BB, Nakamaru-Ogiso E, Marella M, Barber-Singh J, Yamashita T, Matsuno-Yagi A.

Biochim Biophys Acta. 2006 May-Jun;1757(5-6):708-14. Epub 2006 Feb 24. Review.

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