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Items: 1 to 20 of 32

1.

Chemical phylogenetics of histone deacetylases.

Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R.

Nat Chem Biol. 2010 Mar;6(3):238-243. Epub 2010 Feb 7.

2.

Developmental and species-divergent globin switching are driven by BCL11A.

Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH.

Nature. 2009 Aug 27;460(7259):1093-7. doi: 10.1038/nature08243. Epub 2009 Aug 5.

3.

Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges.

Atadja P.

Cancer Lett. 2009 Aug 8;280(2):233-41. doi: 10.1016/j.canlet.2009.02.019. Epub 2009 Apr 2. Review.

PMID:
19344997
4.

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH.

Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4.

5.

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

Lettre G, Sankaran VG, Bezerra MA, Ara├║jo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11869-74. doi: 10.1073/pnas.0804799105. Epub 2008 Jul 30.

6.

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1620-5. doi: 10.1073/pnas.0711566105. Epub 2008 Feb 1.

7.

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

Menzel S, Garner C, Gut I, Matsuda F, Yamaguchi M, Heath S, Foglio M, Zelenika D, Boland A, Rooks H, Best S, Spector TD, Farrall M, Lathrop M, Thein SL.

Nat Genet. 2007 Oct;39(10):1197-9. Epub 2007 Sep 2.

PMID:
17767159
8.

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.

Stegmaier K, Wong JS, Ross KN, Chow KT, Peck D, Wright RD, Lessnick SL, Kung AL, Golub TR.

PLoS Med. 2007 Apr;4(4):e122.

9.

Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements.

Dostie J, Richmond TA, Arnaout RA, Selzer RR, Lee WL, Honan TA, Rubio ED, Krumm A, Lamb J, Nusbaum C, Green RD, Dekker J.

Genome Res. 2006 Oct;16(10):1299-309. Epub 2006 Sep 5.

10.

A method for high-throughput gene expression signature analysis.

Peck D, Crawford ED, Ross KN, Stegmaier K, Golub TR, Lamb J.

Genome Biol. 2006;7(7):R61.

11.

Regulation of human fetal hemoglobin: new players, new complexities.

Bank A.

Blood. 2006 Jan 15;107(2):435-43. Epub 2005 Aug 18. Review.

12.

The active spatial organization of the beta-globin locus requires the transcription factor EKLF.

Drissen R, Palstra RJ, Gillemans N, Splinter E, Grosveld F, Philipsen S, de Laat W.

Genes Dev. 2004 Oct 15;18(20):2485-90.

13.

Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.

Patrinos GP, de Krom M, de Boer E, Langeveld A, Imam AM, Strouboulis J, de Laat W, Grosveld FG.

Genes Dev. 2004 Jun 15;18(12):1495-509.

14.

The beta-globin nuclear compartment in development and erythroid differentiation.

Palstra RJ, Tolhuis B, Splinter E, Nijmeijer R, Grosveld F, de Laat W.

Nat Genet. 2003 Oct;35(2):190-4. Epub 2003 Sep 21.

PMID:
14517543
15.

Induction of human gamma globin gene expression by histone deacetylase inhibitors.

Cao H, Stamatoyannopoulos G, Jung M.

Blood. 2004 Jan 15;103(2):701-9. Epub 2003 Aug 14.

16.

Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease.

Saunthararajah Y, Hillery CA, Lavelle D, Molokie R, Dorn L, Bressler L, Gavazova S, Chen YH, Hoffman R, DeSimone J.

Blood. 2003 Dec 1;102(12):3865-70. Epub 2003 Aug 7.

17.

Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays.

Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL.

Chem Biol. 2003 May;10(5):383-96.

PMID:
12770821
18.
19.

Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment.

Steinberg MH, Barton F, Castro O, Pegelow CH, Ballas SK, Kutlar A, Orringer E, Bellevue R, Olivieri N, Eckman J, Varma M, Ramirez G, Adler B, Smith W, Carlos T, Ataga K, DeCastro L, Bigelow C, Saunthararajah Y, Telfer M, Vichinsky E, Claster S, Shurin S, Bridges K, Waclawiw M, Bonds D, Terrin M.

JAMA. 2003 Apr 2;289(13):1645-51. Erratum in: JAMA. 2003 Aug 13;290(6):756.

PMID:
12672732
20.

HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low-dose dexamethasone.

Gabbianelli M, Testa U, Massa A, Morsilli O, Saulle E, Sposi NM, Petrucci E, Mariani G, Peschle C.

Blood. 2003 Apr 1;101(7):2826-32. Epub 2002 Nov 7.

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