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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.

Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP.

PLoS One. 2010 Mar 19;5(3):e9646. doi: 10.1371/journal.pone.0009646.


Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.

Brauer PM, Tyner AL.

Biochim Biophys Acta. 2010 Aug;1806(1):66-73. doi: 10.1016/j.bbcan.2010.02.003. Review.


Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.

Palka-Hamblin HL, Gierut JJ, Bie W, Brauer PM, Zheng Y, Asara JM, Tyner AL.

J Cell Sci. 2010 Jan 15;123(Pt 2):236-45. doi: 10.1242/jcs.053264.


Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.

Haegebarth A, Perekatt AO, Bie W, Gierut JJ, Tyner AL.

Gastroenterology. 2009 Sep;137(3):945-54. doi: 10.1053/j.gastro.2009.05.054.


Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus.

Ie Kim H, Lee ST.

J Biochem. 2009 Jul;146(1):133-9. doi: 10.1093/jb/mvp050.


c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.

Lodeiro M, Theodoropoulou M, Pardo M, Casanueva FF, Camiña JP.

PLoS One. 2009;4(3):e4686. doi: 10.1371/journal.pone.0004686.


Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.

Robey RB, Hay N.

Semin Cancer Biol. 2009 Feb;19(1):25-31. doi: 10.1016/j.semcancer.2008.11.010. Review.


Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.

Shen CH, Chen HY, Lin MS, Li FY, Chang CC, Kuo ML, Settleman J, Chen RH.

Cancer Res. 2008 Oct 1;68(19):7779-87. doi: 10.1158/0008-5472.CAN-08-0997.


Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.

Aubele M, Walch AK, Ludyga N, Braselmann H, Atkinson MJ, Luber B, Auer G, Tapio S, Cooke T, Bartlett JM.

Br J Cancer. 2008 Oct 7;99(7):1089-95. doi: 10.1038/sj.bjc.6604660.


Brk is coamplified with ErbB2 to promote proliferation in breast cancer.

Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12463-8. doi: 10.1073/pnas.0805009105.


AKT/PKB signaling: navigating downstream.

Manning BD, Cantley LC.

Cell. 2007 Jun 29;129(7):1261-74. Review.


PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas.

Aubele M, Auer G, Walch AK, Munro A, Atkinson MJ, Braselmann H, Fornander T, Bartlett JM.

Br J Cancer. 2007 Mar 12;96(5):801-7.


SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.

Cell. 2006 Oct 6;127(1):125-37.


The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovary.

Schmandt RE, Bennett M, Clifford S, Thornton A, Jiang F, Broaddus RR, Sun CC, Lu KH, Sood AK, Gershenson DM.

Cancer Biol Ther. 2006 Sep;5(9):1136-41.


Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.

Haegebarth A, Bie W, Yang R, Crawford SE, Vasioukhin V, Fuchs E, Tyner AL.

Mol Cell Biol. 2006 Jul;26(13):4949-57.


Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.

Lukong KE, Larocque D, Tyner AL, Richard S.

J Biol Chem. 2005 Nov 18;280(46):38639-47.


Activation of AKT kinases in cancer: implications for therapeutic targeting.

Bellacosa A, Kumar CC, Di Cristofano A, Testa JR.

Adv Cancer Res. 2005;94:29-86. Review.


Role of breast tumour kinase in the in vitro differentiation of HaCaT cells.

Wang TC, Jee SH, Tsai TF, Huang YL, Tsai WL, Chen RH.

Br J Dermatol. 2005 Aug;153(2):282-9.


Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases.

Jung HS, Kim DW, Jo YS, Chung HK, Song JH, Park JS, Park KC, Park SH, Hwang JH, Jo KW, Shong M.

Mol Endocrinol. 2005 Nov;19(11):2748-59.

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