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Items: 1 to 20 of 160

1.

The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.

Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM.

J Biol Chem. 2010 Jun 11;285(24):18877-87. doi: 10.1074/jbc.M110.105668. Epub 2010 Apr 13.

2.

PARP1 deficiency exacerbates diet-induced obesity in mice.

Devalaraja-Narashimha K, Padanilam BJ.

J Endocrinol. 2010 Jun;205(3):243-52. doi: 10.1677/JOE-09-0402. Epub 2010 Mar 25.

3.

Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency.

Nasta F, Laudisi F, Sambucci M, Rosado MM, Pioli C.

J Immunol. 2010 Apr 1;184(7):3470-7. doi: 10.4049/jimmunol.0901568. Epub 2010 Mar 5.

4.

PARP inhibition: PARP1 and beyond.

Rouleau M, Patel A, Hendzel MJ, Kaufmann SH, Poirier GG.

Nat Rev Cancer. 2010 Apr;10(4):293-301. doi: 10.1038/nrc2812. Epub 2010 Mar 4. Review.

5.

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F.

Trends Biochem Sci. 2010 Apr;35(4):208-19. doi: 10.1016/j.tibs.2009.12.003. Epub 2010 Jan 26. Review.

PMID:
20106667
6.

Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).

Eustermann S, Brockmann C, Mehrotra PV, Yang JC, Loakes D, West SC, Ahel I, Neuhaus D.

Nat Struct Mol Biol. 2010 Feb;17(2):241-3. doi: 10.1038/nsmb.1747. Epub 2010 Jan 24.

7.

Solution structure of a zinc-finger domain that binds to poly-ADP-ribose.

Isogai S, Kanno S, Ariyoshi M, Tochio H, Ito Y, Yasui A, Shirakawa M.

Genes Cells. 2010 Feb;15(2):101-10. doi: 10.1111/j.1365-2443.2009.01369.x. Epub 2010 Jan 19.

8.

Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation.

Farrar D, Rai S, Chernukhin I, Jagodic M, Ito Y, Yammine S, Ohlsson R, Murrell A, Klenova E.

Mol Cell Biol. 2010 Mar;30(5):1199-216. doi: 10.1128/MCB.00827-09. Epub 2009 Dec 28.

9.

A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation.

Stilmann M, Hinz M, Arslan SC, Zimmer A, Schreiber V, Scheidereit C.

Mol Cell. 2009 Nov 13;36(3):365-78. doi: 10.1016/j.molcel.2009.09.032.

10.

Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori.

Nossa CW, Jain P, Tamilselvam B, Gupta VR, Chen LF, Schreiber V, Desnoyers S, Blanke SR.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19998-20003. doi: 10.1073/pnas.0906753106. Epub 2009 Nov 6.

11.

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors.

Inbar-Rozensal D, Castiel A, Visochek L, Castel D, Dantzer F, Izraeli S, Cohen-Armon M.

Breast Cancer Res. 2009;11(6):R78. doi: 10.1186/bcr2445. Epub 2009 Nov 9.

12.

SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions.

Zhang T, Kraus WL.

Biochim Biophys Acta. 2010 Aug;1804(8):1666-75. doi: 10.1016/j.bbapap.2009.10.022. Epub 2009 Oct 30. Review.

13.

Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells.

Frizzell KM, Gamble MJ, Berrocal JG, Zhang T, Krishnakumar R, Cen Y, Sauve AA, Kraus WL.

J Biol Chem. 2009 Dec 4;284(49):33926-38. doi: 10.1074/jbc.M109.023879. Epub 2009 Oct 7.

14.

Learning how to read ADP-ribosylation.

Kleine H, Lüscher B.

Cell. 2009 Oct 2;139(1):17-9. doi: 10.1016/j.cell.2009.09.018.

15.

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.

Martin N, Schwamborn K, Schreiber V, Werner A, Guillier C, Zhang XD, Bischof O, Seeler JS, Dejean A.

EMBO J. 2009 Nov 18;28(22):3534-48. doi: 10.1038/emboj.2009.279. Epub 2009 Sep 24.

16.

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.

Nature. 2009 Oct 1;461(7264):614-20. doi: 10.1038/nature08356. Epub 2009 Sep 16.

PMID:
19759537
17.

New functions for an ancient domain.

Kraus WL.

Nat Struct Mol Biol. 2009 Sep;16(9):904-7. No abstract available.

PMID:
19739287
18.

Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.

Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL.

Nat Immunol. 2009 Sep;10(9):958-64. doi: 10.1038/ni.1775. Epub 2009 Aug 16. Erratum in: Nat Immunol. 2010 Jan;11(1):97.

19.

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG.

Nat Struct Mol Biol. 2009 Sep;16(9):923-9. doi: 10.1038/nsmb.1664. Epub 2009 Aug 13.

PMID:
19680243
20.

Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.

El Ramy R, Magroun N, Messadecq N, Gauthier LR, Boussin FD, Kolthur-Seetharam U, Schreiber V, McBurney MW, Sassone-Corsi P, Dantzer F.

Cell Mol Life Sci. 2009 Oct;66(19):3219-34. doi: 10.1007/s00018-009-0105-4. Epub 2009 Aug 12.

PMID:
19672559

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