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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.

DeBerardinis RJ, Cheng T.

Oncogene. 2010 Jan 21;29(3):313-24. doi: 10.1038/onc.2009.358. Epub 2009 Nov 2. Review.



Warburg O, Wind F, Negelein E.

J Gen Physiol. 1927 Mar 7;8(6):519-30. No abstract available.


Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K.

Cancer Res. 2009 Oct 1;69(19):7507-11. doi: 10.1158/0008-5472.CAN-09-2994. Epub 2009 Sep 14. Erratum in: Cancer Res. 2009 Nov 15;69(22):8832.


Targeting the phosphoinositide 3-kinase pathway in cancer.

Liu P, Cheng H, Roberts TM, Zhao JJ.

Nat Rev Drug Discov. 2009 Aug;8(8):627-44. doi: 10.1038/nrd2926. Review.


ATP-citrate lyase links cellular metabolism to histone acetylation.

Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB.

Science. 2009 May 22;324(5930):1076-80. doi: 10.1126/science.1164097.


Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Vander Heiden MG, Cantley LC, Thompson CB.

Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809. Review.


Targeting the mTOR signaling network for cancer therapy.

Meric-Bernstam F, Gonzalez-Angulo AM.

J Clin Oncol. 2009 May 1;27(13):2278-87. doi: 10.1200/JCO.2008.20.0766. Epub 2009 Mar 30. Review.


c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.

Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV.

Nature. 2009 Apr 9;458(7239):762-5. doi: 10.1038/nature07823. Epub 2009 Feb 15.


Bidirectional transport of amino acids regulates mTOR and autophagy.

Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM, Murphy LO.

Cell. 2009 Feb 6;136(3):521-34. doi: 10.1016/j.cell.2008.11.044.


Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7. doi: 10.1073/pnas.0810199105. Epub 2008 Nov 24.


Myc's broad reach.

Eilers M, Eisenman RN.

Genes Dev. 2008 Oct 15;22(20):2755-66. doi: 10.1101/gad.1712408. Review.


Targeting aspartate aminotransferase in breast cancer.

Thornburg JM, Nelson KK, Clem BF, Lane AN, Arumugam S, Simmons A, Eaton JW, Telang S, Chesney J.

Breast Cancer Res. 2008;10(5):R84. doi: 10.1186/bcr2154. Epub 2008 Oct 15.


Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

Dykens JA, Jamieson J, Marroquin L, Nadanaciva S, Billis PA, Will Y.

Toxicol Appl Pharmacol. 2008 Dec 1;233(2):203-10. doi: 10.1016/j.taap.2008.08.013. Epub 2008 Sep 10.


Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.

Hasan NM, Longacre MJ, Stoker SW, Boonsaen T, Jitrapakdee S, Kendrick MA, Wallace JC, MacDonald MJ.

J Biol Chem. 2008 Oct 17;283(42):28048-59. doi: 10.1074/jbc.M804170200. Epub 2008 Aug 12.


Global regulation of nucleotide biosynthetic genes by c-Myc.

Liu YC, Li F, Handler J, Huang CR, Xiang Y, Neretti N, Sedivy JM, Zeller KI, Dang CV.

PLoS One. 2008 Jul 16;3(7):e2722. doi: 10.1371/journal.pone.0002722.


Tumor cell metabolism: cancer's Achilles' heel.

Kroemer G, Pouyssegur J.

Cancer Cell. 2008 Jun;13(6):472-82. doi: 10.1016/j.ccr.2008.05.005. Review.


The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F.

Oncogene. 2008 Jun 5;27(25):3576-86. doi: 10.1038/sj.onc.1211024. Epub 2008 Jan 21.


The interplay between MYC and HIF in cancer.

Dang CV, Kim JW, Gao P, Yustein J.

Nat Rev Cancer. 2008 Jan;8(1):51-6. Review.


Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.

DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19345-50. Epub 2007 Nov 21.


Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.

Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB.

Cancer Res. 2007 Jul 15;67(14):6745-52.

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