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Items: 1 to 20 of 46


The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.

Forrest LR, Rudnick G.

Physiology (Bethesda). 2009 Dec;24:377-86. doi: 10.1152/physiol.00030.2009. Review.


Alternating access of the putative substrate-binding chamber in the ABC transporter MsbA.

Zou P, McHaourab HS.

J Mol Biol. 2009 Oct 30;393(3):574-85. doi: 10.1016/j.jmb.2009.08.051. Epub 2009 Aug 26.


Conformational cycle of the ABC transporter MsbA in liposomes: detailed analysis using double electron-electron resonance spectroscopy.

Zou P, Bortolus M, McHaourab HS.

J Mol Biol. 2009 Oct 30;393(3):586-97. doi: 10.1016/j.jmb.2009.08.050. Epub 2009 Aug 26.


Structure and mechanism of a Na+-independent amino acid transporter.

Shaffer PL, Goehring A, Shankaranarayanan A, Gouaux E.

Science. 2009 Aug 21;325(5943):1010-4. doi: 10.1126/science.1176088. Epub 2009 Jul 16.


Structure of a prokaryotic virtual proton pump at 3.2 A resolution.

Fang Y, Jayaram H, Shane T, Kolmakova-Partensky L, Wu F, Williams C, Xiong Y, Miller C.

Nature. 2009 Aug 20;460(7258):1040-3. doi: 10.1038/nature08201. Epub 2009 Jul 5.


Structure and mechanism of an amino acid antiporter.

Gao X, Lu F, Zhou L, Dang S, Sun L, Li X, Wang J, Shi Y.

Science. 2009 Jun 19;324(5934):1565-8. doi: 10.1126/science.1173654. Epub 2009 May 28.


Unlocking the molecular secrets of sodium-coupled transporters.

Krishnamurthy H, Piscitelli CL, Gouaux E.

Nature. 2009 May 21;459(7245):347-55. doi: 10.1038/nature08143. Review.


Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.

Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN.

Nat Struct Mol Biol. 2009 Jun;16(6):652-7. doi: 10.1038/nsmb.1602. Epub 2009 May 10.


Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.

Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5563-8. doi: 10.1073/pnas.0811322106. Epub 2009 Mar 23.


Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP.

Ressl S, Terwisscha van Scheltinga AC, Vonrhein C, Ott V, Ziegler C.

Nature. 2009 Mar 5;458(7234):47-52. doi: 10.1038/nature07819.


A competitive inhibitor traps LeuT in an open-to-out conformation.

Singh SK, Piscitelli CL, Yamashita A, Gouaux E.

Science. 2008 Dec 12;322(5908):1655-61. doi: 10.1126/science.1166777.


Review. The molecular logic of sodium-coupled neurotransmitter transporters.

Gouaux E.

Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):149-54. doi: 10.1098/rstb.2008.0181. Review.


Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter.

Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD.

Science. 2008 Oct 31;322(5902):709-13. doi: 10.1126/science.1164440. Epub 2008 Oct 16.


Molecular mechanism of ion-ion and ion-substrate coupling in the Na+-dependent leucine transporter LeuT.

Caplan DA, Subbotina JO, Noskov SY.

Biophys J. 2008 Nov 15;95(10):4613-21. doi: 10.1529/biophysj.108.139741. Epub 2008 Aug 15.


Mechanism for alternating access in neurotransmitter transporters.

Forrest LR, Zhang YW, Jacobs MT, Gesmonde J, Xie L, Honig BH, Rudnick G.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10338-43. doi: 10.1073/pnas.0804659105. Epub 2008 Jul 22.


The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport.

Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J.

Science. 2008 Aug 8;321(5890):810-4. doi: 10.1126/science.1160406. Epub 2008 Jul 3.


The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.

Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA.

Mol Cell. 2008 Jun 20;30(6):667-77. doi: 10.1016/j.molcel.2008.05.008.


Molecular mechanism of substrate specificity in the bacterial neutral amino acid transporter LeuT.

Noskov SY.

Proteins. 2008 Dec;73(4):851-63. doi: 10.1002/prot.22108.


An intracellular interaction network regulates conformational transitions in the dopamine transporter.

Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U.

J Biol Chem. 2008 Jun 20;283(25):17691-701. doi: 10.1074/jbc.M800475200. Epub 2008 Apr 21.


Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms.

Noskov SY, Roux B.

J Mol Biol. 2008 Mar 28;377(3):804-18. doi: 10.1016/j.jmb.2008.01.015. Epub 2008 Jan 15.

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