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The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B.

Privratsky JR, Tourdot BE, Newman DK, Newman PJ.

J Immunol. 2010 Mar 15;184(6):3157-63. doi: 10.4049/jimmunol.0901944. Epub 2010 Feb 19.


Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment.

Mamdouh Z, Mikhailov A, Muller WA.

J Exp Med. 2009 Nov 23;206(12):2795-808. doi: 10.1084/jem.20082745. Epub 2009 Nov 2.


Blocking platelet/endothelial cell adhesion molecule 1 (PECAM) inhibits disease progression and prevents joint erosion in established collagen antibody-induced arthritis.

Dasgupta B, Chew T, deRoche A, Muller WA.

Exp Mol Pathol. 2010 Feb;88(1):210-5. doi: 10.1016/j.yexmp.2009.09.013. Epub 2009 Oct 2.


PECAM-1 is necessary for flow-induced vascular remodeling.

Chen Z, Tzima E.

Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1067-73. doi: 10.1161/ATVBAHA.109.186692. Epub 2009 Apr 23.


A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration.

Dasgupta B, Dufour E, Mamdouh Z, Muller WA.

J Immunol. 2009 Apr 15;182(8):5041-51. doi: 10.4049/jimmunol.0803192.


Rapid changes in shear stress induce dissociation of a G alpha(q/11)-platelet endothelial cell adhesion molecule-1 complex.

Otte LA, Bell KS, Loufrani L, Yeh JC, Melchior B, Dao DN, Stevens HY, White CR, Frangos JA.

J Physiol. 2009 May 15;587(Pt 10):2365-73. doi: 10.1113/jphysiol.2009.172643. Epub 2009 Mar 30.


Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.

Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B, Nourshargh S.

Blood. 2009 Jun 11;113(24):6246-57. doi: 10.1182/blood-2008-11-188375. Epub 2009 Feb 10.


PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2.

Seidman MA, Chew TW, Schenkel AR, Muller WA.

PLoS One. 2009;4(1):e4316. doi: 10.1371/journal.pone.0004316. Epub 2009 Jan 30.


PECAM-1 is a critical mediator of atherosclerosis.

Stevens HY, Melchior B, Bell KS, Yun S, Yeh JC, Frangos JA.

Dis Model Mech. 2008 Sep-Oct;1(2-3):175-81; discussion 179. doi: 10.1242/dmm.000547. Epub 2008 Sep 18.


Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice.

Harry BL, Sanders JM, Feaver RE, Lansey M, Deem TL, Zarbock A, Bruce AC, Pryor AW, Gelfand BD, Blackman BR, Schwartz MA, Ley K.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2003-8. doi: 10.1161/ATVBAHA.108.164707. Epub 2008 Aug 7.


Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.

Yeh JC, Otte LA, Frangos JA.

Biochemistry. 2008 Aug 26;47(34):9029-39. doi: 10.1021/bi8003846. Epub 2008 Aug 2.


Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice.

Goel R, Schrank BR, Arora S, Boylan B, Fleming B, Miura H, Newman PJ, Molthen RC, Newman DK.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1996-2002. doi: 10.1161/ATVBAHA.108.172270. Epub 2008 Jul 31.


Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn.

Huang YT, Chen SU, Chou CH, Lee H.

Cell Signal. 2008 Aug;20(8):1521-7. doi: 10.1016/j.cellsig.2008.04.008. Epub 2008 Apr 18.


Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment.

Mamdouh Z, Kreitzer GE, Muller WA.

J Exp Med. 2008 Apr 14;205(4):951-66. doi: 10.1084/jem.20072328. Epub 2008 Mar 31.


PECAM-1 isoform-specific functions in PECAM-1-deficient brain microvascular endothelial cells.

DiMaio TA, Sheibani N.

Microvasc Res. 2008 Mar;75(2):188-201. Epub 2007 Oct 17.


PECAM-1 ligation negatively regulates TLR4 signaling in macrophages.

Rui Y, Liu X, Li N, Jiang Y, Chen G, Cao X, Wang J.

J Immunol. 2007 Dec 1;179(11):7344-51.


Dual regulation of endothelial junctional permeability.

Komarova YA, Mehta D, Malik AB.

Sci STKE. 2007 Nov 13;2007(412):re8. Review.


The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis.

Goel R, Boylan B, Gruman L, Newman PJ, North PE, Newman DK.

Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1205-14. Epub 2007 Oct 11.


PECAM-1: a multi-functional molecule in inflammation and vascular biology.

Woodfin A, Voisin MB, Nourshargh S.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2514-23. Epub 2007 Sep 13. Review.

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