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Items: 1 to 20 of 28


A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

Xu M, Skaug B, Zeng W, Chen ZJ.

Mol Cell. 2009 Oct 23;36(2):302-14. doi: 10.1016/j.molcel.2009.10.002.


Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling.

Nakamura A, Naito M, Tsuruo T, Fujita N.

Mol Cell Biol. 2008 Oct;28(19):5996-6009. doi: 10.1128/MCB.00114-08. Epub 2008 Jul 28.


Shared principles in NF-kappaB signaling.

Hayden MS, Ghosh S.

Cell. 2008 Feb 8;132(3):344-62. doi: 10.1016/j.cell.2008.01.020. Review.


Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis.

Childress JL, Acar M, Tao C, Halder G.

Curr Biol. 2006 Nov 21;16(22):2228-33. Epub 2006 Nov 9.


Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.

Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, Fässler R.

Cell. 2006 May 19;125(4):665-77.


A genomic and functional inventory of deubiquitinating enzymes.

Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, Sixma TK, Bernards R.

Cell. 2005 Dec 2;123(5):773-86. Review.


The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation.

Basel-Vanagaite L, Attia R, Yahav M, Ferland RJ, Anteki L, Walsh CA, Olender T, Straussberg R, Magal N, Taub E, Drasinover V, Alkelai A, Bercovich D, Rechavi G, Simon AJ, Shohat M.

J Med Genet. 2006 Mar;43(3):203-10. Epub 2005 Jul 20.


Signaling via NF-kappaB in the nervous system.

Kaltschmidt B, Widera D, Kaltschmidt C.

Biochim Biophys Acta. 2005 Sep 30;1745(3):287-99. Review.


Physiological functions for brain NF-kappaB.

Meffert MK, Baltimore D.

Trends Neurosci. 2005 Jan;28(1):37-43. Review.


Ubiquitin: a Nobel protein.

Wilkinson KD.

Cell. 2004 Dec 17;119(6):741-5. No abstract available.


Mechanism and function of deubiquitinating enzymes.

Amerik AY, Hochstrasser M.

Biochim Biophys Acta. 2004 Nov 29;1695(1-3):189-207. Review.


Back to the future with ubiquitin.

Pickart CM.

Cell. 2004 Jan 23;116(2):181-90. Review.


The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

Kovalenko A, Chable-Bessia C, Cantarella G, Israël A, Wallach D, Courtois G.

Nature. 2003 Aug 14;424(6950):801-5.


Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

Brummelkamp TR, Nijman SM, Dirac AM, Bernards R.

Nature. 2003 Aug 14;424(6950):797-801.


CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G.

Nature. 2003 Aug 14;424(6950):793-6.


Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene.

Ou XM, Lemonde S, Jafar-Nejad H, Bown CD, Goto A, Rogaeva A, Albert PR.

J Neurosci. 2003 Aug 13;23(19):7415-25.


Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S.

Oncogene. 2003 May 22;22(21):3307-18.


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