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Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy.

Hamann L, Kumpf O, Schuring RP, Alpsoy E, Bedu-Addo G, Bienzle U, Oskam L, Mockenhaupt FP, Schumann RR.

BMC Med Genet. 2009 Jul 14;10:65. doi: 10.1186/1471-2350-10-65.


Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.

Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG.

Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10272-7. doi: 10.1073/pnas.0811273106. Epub 2009 Jun 9.


Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis).

Wiersinga WJ, van't Veer C, van den Pangaart PS, Dondorp AM, Day NP, Peacock SJ, van der Poll T.

Crit Care Med. 2009 Feb;37(2):569-76. doi: 10.1097/CCM.0b013e318194b1bf.


TLR signaling pathway in patients with sepsis.

Salomão R, Martins PS, Brunialti MK, Fernandes Mda L, Martos LS, Mendes ME, Gomes NE, Rigato O.

Shock. 2008 Oct;30 Suppl 1:73-7. doi: 10.1097/SHK.0b013e318181af2a. Review.


Inflammatory response and cardioprotection during open-heart surgery: the importance of anaesthetics.

Suleiman MS, Zacharowski K, Angelini GD.

Br J Pharmacol. 2008 Jan;153(1):21-33. Epub 2007 Oct 22. Review.


Recognition of microorganisms and activation of the immune response.

Medzhitov R.

Nature. 2007 Oct 18;449(7164):819-26. Review.


TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans.

Ferwerda B, McCall MB, Alonso S, Giamarellos-Bourboulis EJ, Mouktaroudi M, Izagirre N, Syafruddin D, Kibiki G, Cristea T, Hijmans A, Hamann L, Israel S, ElGhazali G, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Hermsen CC, Stalenhoef AF, van Crevel R, Brunner HG, Oh DY, Schumann RR, de la Rúa C, Sauerwein R, Kullberg BJ, van der Ven AJ, van der Meer JW, Netea MG.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16645-50. Epub 2007 Oct 9.


Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.

Biswas SK, Bist P, Dhillon MK, Kajiji T, Del Fresno C, Yamamoto M, Lopez-Collazo E, Akira S, Tergaonkar V.

J Immunol. 2007 Sep 15;179(6):4083-92.


The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

Mata-Haro V, Cekic C, Martin M, Chilton PM, Casella CR, Mitchell TC.

Science. 2007 Jun 15;316(5831):1628-32.


Pathophysiology of sepsis.

Remick DG.

Am J Pathol. 2007 May;170(5):1435-44. Review. Erratum in: Am J Pathol. 2007 Sep;171(3):1078.


Stress molecules in sepsis and systemic inflammatory response syndrome.

Adib-Conquy M, Cavaillon JM.

FEBS Lett. 2007 Jul 31;581(19):3723-33. Epub 2007 Apr 4. Review.


A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O'Neill LA, Hill AV.

Nat Genet. 2007 Apr;39(4):523-8. Epub 2007 Feb 25.


A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis.

Hawn TR, Dunstan SJ, Thwaites GE, Simmons CP, Thuong NT, Lan NTN, Quy HT, Chau TTH, Hieu NT, Rodrigues S, Janer M, Zhao LP, Hien TT, Farrar JJ, Aderem A.

J Infect Dis. 2006 Oct 15;194(8):1127-1134. doi: 10.1086/507907. Epub 2006 Sep 12.


Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4).

Calvano JE, Bowers DJ, Coyle SM, Macor M, Reddell MT, Kumar A, Calvano SE, Lowry SF.

Clin Immunol. 2006 Nov;121(2):186-90. Epub 2006 Jul 7.


Early apoptosis of blood monocytes in the septic host: is it a mechanism of protection in the event of septic shock?

Giamarellos-Bourboulis EJ, Routsi C, Plachouras D, Markaki V, Raftogiannis M, Zervakis D, Koussoulas V, Orfanos S, Kotanidou A, Armaganidis A, Roussos C, Giamarellou H.

Crit Care. 2006;10(3):R76. Epub 2006 May 12.


Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome.

Zacharowski K, Zacharowski PA, Koch A, Baban A, Tran N, Berkels R, Papewalis C, Schulze-Osthoff K, Knuefermann P, Zähringer U, Schumann RR, Rettori V, McCann SM, Bornstein SR.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6392-7. Epub 2006 Apr 10.


Pathogen recognition and innate immunity.

Akira S, Uematsu S, Takeuchi O.

Cell. 2006 Feb 24;124(4):783-801. Review.


Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis.

Giamarellos-Bourboulis EJ, Zakynthinos S, Baziaka F, Papadomichelakis E, Virtzili S, Koutoukas P, Armaganidis A, Giamarellou H, Roussos C.

Intensive Care Med. 2006 Feb;32(2):237-243. doi: 10.1007/s00134-005-0017-1. Epub 2006 Feb 1.


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