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Items: 1 to 20 of 36

1.

Caspase activation precedes and leads to tangles.

de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT.

Nature. 2010 Apr 22;464(7292):1201-4. doi: 10.1038/nature08890. Epub 2010 Mar 31.

2.

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH.

Neuron. 2010 Jan 14;65(1):66-79. doi: 10.1016/j.neuron.2009.12.023.

3.

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ.

J Pharmacol Exp Ther. 2010 Mar;332(3):849-57. doi: 10.1124/jpet.109.158436. Epub 2009 Nov 24.

4.

Establishment of stably transfected rat neuronal cell lines expressing alpha-synuclein GFP fusion proteins.

Schwach G, Tschemmernegg M, Pfragner R, Ingolic E, Schreiner E, Windisch M.

J Mol Neurosci. 2010 May;41(1):80-8. doi: 10.1007/s12031-009-9289-1. Epub 2009 Oct 9.

PMID:
19816809
5.

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM.

Science. 2009 Nov 13;326(5955):1005-7. doi: 10.1126/science.1180962. Epub 2009 Sep 24.

6.

Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.

Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee JM.

J Neurosci. 2009 Aug 26;29(34):10706-14. doi: 10.1523/JNEUROSCI.2637-09.2009.

7.

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window.

Holtmaat A, Bonhoeffer T, Chow DK, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee WC, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L.

Nat Protoc. 2009;4(8):1128-44. doi: 10.1038/nprot.2009.89. Epub 2009 Jul 16.

8.

GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.

Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, Ney PA, Ng J, McGoldrick M, Mollenhauer B, Bresnick EH, Schlossmacher MG.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10907-12. doi: 10.1073/pnas.0802437105. Epub 2008 Jul 31.

9.

Nurr1 transcriptionally regulates the expression of alpha-synuclein.

Yang YX, Latchman DS.

Neuroreport. 2008 May 28;19(8):867-71. doi: 10.1097/WNR.0b013e3282ffda48.

PMID:
18463503
10.

Formation of toxic oligomeric alpha-synuclein species in living cells.

Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ.

PLoS One. 2008 Apr 2;3(4):e1867. doi: 10.1371/journal.pone.0001867. Erratum in: PLoS One. 2008;3(5). doi: 10.1371/annotation/9282f173-df82-4b70-9120-b4e62b3dacb1.

11.

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.

van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterk RH, Nollen EA.

PLoS Genet. 2008 Mar 21;4(3):e1000027. doi: 10.1371/journal.pgen.1000027.

12.

Dequalinium-induced cell death of yeast expressing alpha-synuclein-GFP fusion protein.

Lee IH, Kim HY, Kim M, Hahn JS, Paik SR.

Neurochem Res. 2008 Jul;33(7):1393-400. doi: 10.1007/s11064-008-9598-8. Epub 2008 Mar 7.

PMID:
18322792
13.

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.

Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT.

Nature. 2008 Feb 7;451(7179):720-4. doi: 10.1038/nature06616.

14.

In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.

Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT.

J Neurosci. 2008 Jan 23;28(4):862-7. doi: 10.1523/JNEUROSCI.3072-08.2008.

15.

Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex.

Xu HT, Pan F, Yang G, Gan WB.

Nat Neurosci. 2007 May;10(5):549-51. Epub 2007 Apr 8.

PMID:
17417634
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18.

Two-photon imaging of synaptic plasticity and pathology in the living mouse brain.

Grutzendler J, Gan WB.

NeuroRx. 2006 Oct;3(4):489-96. Review.

19.

Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers.

Beyer K.

Acta Neuropathol. 2006 Sep;112(3):237-51. Epub 2006 Jul 15. Review.

PMID:
16845533
20.

Neural activity controls the synaptic accumulation of alpha-synuclein.

Fortin DL, Nemani VM, Voglmaier SM, Anthony MD, Ryan TA, Edwards RH.

J Neurosci. 2005 Nov 23;25(47):10913-21.

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