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Items: 1 to 20 of 53

1.

Protein kinase Calpha: disease regulator and therapeutic target.

Konopatskaya O, Poole AW.

Trends Pharmacol Sci. 2010 Jan;31(1):8-14. doi: 10.1016/j.tips.2009.10.006. Epub 2009 Dec 5. Review.

2.

PKCtheta in platelet activation.

Harper MT, Poole AW.

Blood. 2009 Jul 9;114(2):489-91; author reply 491-2. doi: 10.1182/blood-2009-03-208454. No abstract available.

3.

PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion.

Cohen S, Braiman A, Shubinsky G, Ohayon A, Altman A, Isakov N.

Biochem Biophys Res Commun. 2009 Jul 17;385(1):22-7. doi: 10.1016/j.bbrc.2009.05.021. Epub 2009 May 9.

PMID:
19433059
4.

Protein kinase C[delta] differentially regulates platelet functional responses.

Chari R, Getz T, Nagy B Jr, Bhavaraju K, Mao Y, Bynagari YS, Murugappan S, Nakayama K, Kunapuli SP.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):699-705. doi: 10.1161/ATVBAHA.109.184010. Epub 2009 Feb 12.

5.

Impaired activation of platelets lacking protein kinase C-theta isoform.

Nagy B Jr, Bhavaraju K, Getz T, Bynagari YS, Kim S, Kunapuli SP.

Blood. 2009 Mar 12;113(11):2557-67. doi: 10.1182/blood-2008-07-169268. Epub 2009 Jan 22.

6.

PKCalpha regulates platelet granule secretion and thrombus formation in mice.

Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, Heemskerk JW, Poole AW.

J Clin Invest. 2009 Feb;119(2):399-407. doi: 10.1172/JCI34665. Epub 2009 Jan 19.

7.

Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets.

Pears CJ, Thornber K, Auger JM, Hughes CE, Grygielska B, Protty MB, Pearce AC, Watson SP.

PLoS One. 2008;3(11):e3793. doi: 10.1371/journal.pone.0003793. Epub 2008 Nov 24.

8.

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.

Hall KJ, Harper MT, Gilio K, Cosemans JM, Heemskerk JW, Poole AW.

PLoS One. 2008 Sep 25;3(9):e3277. doi: 10.1371/journal.pone.0003277.

9.

Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

van der Meijden PE, Schoenwaelder SM, Feijge MA, Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW.

FEBS J. 2008 Jan;275(2):371-85. Epub 2007 Dec 13. Erratum in: FEBS J. 2008 Feb;275(4):811.

10.

Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation.

Munnix IC, Kuijpers MJ, Auger J, Thomassen CM, Panizzi P, van Zandvoort MA, Rosing J, Bock PE, Watson SP, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2484-90. Epub 2007 Aug 30.

11.

Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets.

Strehl A, Munnix IC, Kuijpers MJ, van der Meijden PE, Cosemans JM, Feijge MA, Nieswandt B, Heemskerk JW.

J Biol Chem. 2007 Mar 9;282(10):7046-55. Epub 2007 Jan 8.

12.

Discovery of potent and selective PKC-theta inhibitors.

Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML.

Bioorg Med Chem Lett. 2007 Jan 1;17(1):225-30. Epub 2006 Oct 19.

PMID:
17055721
14.

PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.

Pula G, Schuh K, Nakayama K, Nakayama KI, Walter U, Poole AW.

Blood. 2006 Dec 15;108(13):4035-44. Epub 2006 Aug 29.

15.

A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.

Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ.

J Thromb Haemost. 2006 Mar;4(3):648-55.

16.

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency.

Mangin P, Yap CL, Nonne C, Sturgeon SA, Goncalves I, Yuan Y, Schoenwaelder SM, Wright CE, Lanza F, Jackson SP.

Blood. 2006 Jun 1;107(11):4346-53. Epub 2006 Jan 3.

17.

Adhesion of human and mouse platelets to collagen under shear: a unifying model.

Auger JM, Kuijpers MJ, Senis YA, Watson SP, Heemskerk JW.

FASEB J. 2005 May;19(7):825-7. Epub 2005 Mar 9.

PMID:
15758040
18.

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

Hardy AR, Conley PB, Luo J, Benovic JL, Poole AW, Mundell SJ.

Blood. 2005 May 1;105(9):3552-60. Epub 2005 Jan 21.

19.

Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets.

Pula G, Crosby D, Baker J, Poole AW.

J Biol Chem. 2005 Feb 25;280(8):7194-205. Epub 2004 Dec 6.

20.

Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta.

Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, Arias-Salgado EG, Kawakami T, Shattil SJ.

J Biol Chem. 2005 Jan 7;280(1):644-53. Epub 2004 Nov 9.

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