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Items: 1 to 20 of 29

1.

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

Wang XJ, Hayes JD, Higgins LG, Wolf CR, Dinkova-Kostova AT.

Chem Biol. 2010 Jan 29;17(1):75-85. doi: 10.1016/j.chembiol.2009.12.013.

2.

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation.

Fourquet S, Guerois R, Biard D, Toledano MB.

J Biol Chem. 2010 Mar 12;285(11):8463-71. doi: 10.1074/jbc.M109.051714. Epub 2010 Jan 8.

3.

Comment on "Assessing the efficacy of nonsteroidal anti-inflammatory drugs through the quantum computation of molecular ionization energies".

Bensasson RV, Berthier G, Zoote V.

J Phys Chem A. 2009 Nov 5;113(44):12337-8. doi: 10.1021/jp9074652. No abstract available.

PMID:
19817358
4.

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

Liu H, Dinkova-Kostova AT, Talalay P.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15926-31. doi: 10.1073/pnas.0808346105. Epub 2008 Oct 6.

5.

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.

Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB.

Cancer Res. 2008 Aug 15;68(16):6727-33. doi: 10.1158/0008-5472.CAN-08-1123.

6.

Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

Liby K, Risingsong R, Royce DB, Williams CR, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB.

Clin Cancer Res. 2008 Jul 15;14(14):4556-63. doi: 10.1158/1078-0432.CCR-08-0040.

7.
8.

Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

Bensasson RV, Zoete V, Dinkova-Kostova AT, Talalay P.

Chem Res Toxicol. 2008 Apr;21(4):805-12. doi: 10.1021/tx7002883. Epub 2008 Mar 25.

PMID:
18361512
9.

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

Liby KT, Yore MM, Sporn MB.

Nat Rev Cancer. 2007 May;7(5):357-69. Epub 2007 Apr 19. Review.

PMID:
17446857
10.

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.

Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW, Dmitrovsky E, Sporn TA, Sporn MB.

Cancer Res. 2007 Mar 15;67(6):2414-9.

11.

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore.

Brookes PS, Morse K, Ray D, Tompkins A, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R, Bernstein SH.

Cancer Res. 2007 Feb 15;67(4):1793-802.

12.
13.

Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression.

Lee-Hilz YY, Boerboom AM, Westphal AH, Berkel WJ, Aarts JM, Rietjens IM.

Chem Res Toxicol. 2006 Nov;19(11):1499-505.

PMID:
17112238
14.

Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

Ahmad R, Raina D, Meyer C, Kharbanda S, Kufe D.

J Biol Chem. 2006 Nov 24;281(47):35764-9. Epub 2006 Sep 24.

15.

Electrophilicity index.

Chattaraj PK, Sarkar U, Roy DR.

Chem Rev. 2006 Jun;106(6):2065-91. No abstract available.

PMID:
16771443
16.

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.

Couch RD, Browning RG, Honda T, Gribble GW, Wright DL, Sporn MB, Anderson AC.

Bioorg Med Chem Lett. 2005 May 2;15(9):2215-9.

PMID:
15837296
17.

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.

Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. Epub 2005 Mar 14.

18.

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital.

Zoete V, Rougée M, Dinkova-Kostova AT, Talalay P, Bensasson RV.

Free Radic Biol Med. 2004 Jun 1;36(11):1418-23.

PMID:
15135178
19.

Induction of quinone reductase as a primary screen for natural product anticarcinogens.

Kang YH, Pezzuto JM.

Methods Enzymol. 2004;382:380-414. Review. No abstract available.

PMID:
15047113
20.

The "Prochaska" microtiter plate bioassay for inducers of NQO1.

Fahey JW, Dinkova-Kostova AT, Stephenson KK, Talalay P.

Methods Enzymol. 2004;382:243-58. Review. No abstract available.

PMID:
15047106

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