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Items: 1 to 20 of 51

1.

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.

Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, Grant S, Curiel DT, Fisher PB, Dent P.

Cancer Res. 2010 Feb 1;70(3):1120-9. doi: 10.1158/0008-5472.CAN-09-4043. Epub 2010 Jan 26.

2.

Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.

Sauane M, Su ZZ, Dash R, Liu X, Norris JS, Sarkar D, Lee SG, Allegood JC, Dent P, Spiegel S, Fisher PB.

J Cell Physiol. 2010 Mar;222(3):546-55. doi: 10.1002/jcp.21969.

PMID:
19937735
3.

Inhibition of autophagy induced by overexpression of mda-7/interleukin-24 strongly augments the antileukemia activity in vitro and in vivo.

Yang C, Tong Y, Ni W, Liu J, Xu W, Li L, Liu X, Meng H, Qian W.

Cancer Gene Ther. 2010 Feb;17(2):109-19. doi: 10.1038/cgt.2009.57. Epub 2009 Sep 4.

PMID:
19730452
4.

Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells.

Tormo D, Checińska A, Alonso-Curbelo D, Pérez-Guijarro E, Cañón E, Riveiro-Falkenbach E, Calvo TG, Larribere L, Megías D, Mulero F, Piris MA, Dash R, Barral PM, Rodríguez-Peralto JL, Ortiz-Romero P, Tüting T, Fisher PB, Soengas MS.

Cancer Cell. 2009 Aug 4;16(2):103-14. doi: 10.1016/j.ccr.2009.07.004.

5.

MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.

Park MA, Walker T, Martin AP, Allegood J, Vozhilla N, Emdad L, Sarkar D, Rahmani M, Graf M, Yacoub A, Koumenis C, Spiegel S, Curiel DT, Voelkel-Johnson C, Grant S, Fisher PB, Dent P.

Mol Cancer Ther. 2009 May;8(5):1280-91. doi: 10.1158/1535-7163.MCT-09-0073. Epub 2009 May 5.

6.

Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells.

Cheng Y, Qiu F, Ye YC, Guo ZM, Tashiro S, Onodera S, Ikejima T.

FEBS J. 2009 Mar;276(5):1291-306. doi: 10.1111/j.1742-4658.2008.06864.x.

7.

The paradox of autophagy and its implication in cancer etiology and therapy.

Eisenberg-Lerner A, Kimchi A.

Apoptosis. 2009 Apr;14(4):376-91. doi: 10.1007/s10495-008-0307-5. Review.

PMID:
19172397
8.

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells.

Cho DH, Jo YK, Hwang JJ, Lee YM, Roh SA, Kim JC.

Cancer Lett. 2009 Feb 8;274(1):95-100. doi: 10.1016/j.canlet.2008.09.004. Epub 2008 Oct 7.

PMID:
18842334
9.

Ad-MDA-7; INGN 241: a review of preclinical and clinical experience.

Eager R, Harle L, Nemunaitis J.

Expert Opin Biol Ther. 2008 Oct;8(10):1633-43. doi: 10.1517/14712598.8.10.1633 . Review.

PMID:
18774929
10.

Does autophagy have a license to kill mammalian cells?

Scarlatti F, Granata R, Meijer AJ, Codogno P.

Cell Death Differ. 2009 Jan;16(1):12-20. doi: 10.1038/cdd.2008.101. Epub 2008 Jul 4. Review.

11.

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

Sauane M, Su ZZ, Gupta P, Lebedeva IV, Dent P, Sarkar D, Fisher PB.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9763-8. doi: 10.1073/pnas.0804089105. Epub 2008 Jul 3.

12.

Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24.

Gao P, Sun X, Chen X, Wang Y, Foster BA, Subjeck J, Fisher PB, Wang XY.

Cancer Res. 2008 May 15;68(10):3890-8. doi: 10.1158/0008-5472.CAN-08-0156.

13.

MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.

Yacoub A, Hamed H, Emdad L, Dos Santos W, Gupta P, Broaddus WC, Ramakrishnan V, Sarkar D, Shah K, Curiel DT, Grant S, Fisher PB, Dent P.

Cancer Biol Ther. 2008 Jun;7(6):917-33. Epub 2008 Mar 19.

PMID:
18376144
14.

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.

Park MA, Yacoub A, Sarkar D, Emdad L, Rahmani M, Spiegel S, Koumenis C, Graf M, Curiel DT, Grant S, Fisher PB, Dent P.

Autophagy. 2008 May;4(4):513-5. Epub 2008 Feb 13.

15.

Autophagy in the pathogenesis of disease.

Levine B, Kroemer G.

Cell. 2008 Jan 11;132(1):27-42. doi: 10.1016/j.cell.2007.12.018. Review.

16.

Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy.

Fujiwara K, Daido S, Yamamoto A, Kobayashi R, Yokoyama T, Aoki H, Iwado E, Shinojima N, Kondo Y, Kondo S.

J Biol Chem. 2008 Jan 4;283(1):388-97. Epub 2007 Oct 24.

17.

mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

Lebedeva IV, Emdad L, Su ZZ, Gupta P, Sauane M, Sarkar D, Staudt MR, Liu SJ, Taher MM, Xiao R, Barral P, Lee SG, Wang D, Vozhilla N, Park ES, Chatman L, Boukerche H, Ramesh R, Inoue S, Chada S, Li R, De Pass AL, Mahasreshti PJ, Dmitriev IP, Curiel DT, Yacoub A, Grant S, Dent P, Senzer N, Nemunaitis JJ, Fisher PB.

Int J Oncol. 2007 Nov;31(5):985-1007. Review.

PMID:
17912425
18.

Eradication of therapy-resistant human prostate tumors using a cancer terminator virus.

Sarkar D, Lebedeva IV, Su ZZ, Park ES, Chatman L, Vozhilla N, Dent P, Curiel DT, Fisher PB.

Cancer Res. 2007 Jun 1;67(11):5434-42.

19.

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?

Sarkar D, Lebedeva IV, Gupta P, Emdad L, Sauane M, Dent P, Curiel DT, Fisher PB.

Expert Opin Biol Ther. 2007 May;7(5):577-86. Review.

PMID:
17477796
20.

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.

Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L, Houghton JA, Huang P, Giles FJ, Cleveland JL.

Blood. 2007 Jul 1;110(1):313-22. Epub 2007 Mar 15.

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