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Items: 8


Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.

Taylor P, Kovarik Z, Reiner E, Radić Z.

Toxicology. 2007 Apr 20;233(1-3):70-8. Epub 2006 Nov 24.


Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity.

Amitai G, Adani R, Yacov G, Yishay S, Teitlboim S, Tveria L, Limanovich O, Kushnir M, Meshulam H.

Toxicology. 2007 Apr 20;233(1-3):187-98. Epub 2006 Oct 13.


Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates.

Kovarik Z, Radić Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P.

Biochemistry. 2004 Mar 23;43(11):3222-9.


Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates.

Kovarik Z, Radić Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P.

Biochem J. 2003 Jul 1;373(Pt 1):33-40.


Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.

Shafferman A, Ordentlich A, Barak D, Stein D, Ariel N, Velan B.

Biochem J. 1996 Sep 15;318 ( Pt 3):833-40.


Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes.

Ashani Y, Radić Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P.

J Biol Chem. 1995 Mar 17;270(11):6370-80.


Chiral reactions of acetylcholinesterase probed with enantiomeric methylphosphonothioates. Noncovalent determinants of enzyme chirality.

Berman HA, Leonard K.

J Biol Chem. 1989 Mar 5;264(7):3942-50. Erratum in: J Biol Chem 1989 Nov 25;264(33):20154.

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