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Items: 1 to 20 of 125


The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS.

Curr Biol. 2009 Aug 11;19(15):1320-6. doi: 10.1016/j.cub.2009.06.046. Epub 2009 Jul 9.


The hedgehog signaling pathway: where did it come from?

Hausmann G, von Mering C, Basler K.

PLoS Biol. 2009 Jun 30;7(6):e1000146. doi: 10.1371/journal.pbio.1000146. Epub 2009 Jun 30. No abstract available.


The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

Cheung HO, Zhang X, Ribeiro A, Mo R, Makino S, Puviindran V, Law KK, Briscoe J, Hui CC.

Sci Signal. 2009 Jun 23;2(76):ra29. doi: 10.1126/scisignal.2000405.


The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling.

Aanstad P, Santos N, Corbit KC, Scherz PJ, Trinh le A, Salvenmoser W, Huisken J, Reiter JF, Stainier DY.

Curr Biol. 2009 Jun 23;19(12):1034-9. doi: 10.1016/j.cub.2009.04.053. Epub 2009 May 21.


Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.

Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, Toftgård R, Liu A.

Dev Biol. 2009 Jun 15;330(2):452-60. doi: 10.1016/j.ydbio.2009.04.009. Epub 2009 Apr 14.


Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

Wilson CW, Chen MH, Chuang PT.

PLoS One. 2009;4(4):e5182. doi: 10.1371/journal.pone.0005182. Epub 2009 Apr 13.


Tulp3 is a critical repressor of mouse hedgehog signaling.

Cameron DA, Pennimpede T, Petkovich M.

Dev Dyn. 2009 May;238(5):1140-9. doi: 10.1002/dvdy.21926.


Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT.

Nature. 2009 May 7;459(7243):98-102. doi: 10.1038/nature07883. Epub 2009 Mar 22.


Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.

Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT.

Hum Mol Genet. 2009 May 15;18(10):1740-54. doi: 10.1093/hmg/ddp113. Epub 2009 Mar 12.


Characterization of mouse IFT complex B.

Follit JA, Xu F, Keady BT, Pazour GJ.

Cell Motil Cytoskeleton. 2009 Aug;66(8):457-68. doi: 10.1002/cm.20346.


Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.

Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN.

Hum Mol Genet. 2009 May 15;18(10):1719-39. doi: 10.1093/hmg/ddp075. Epub 2009 Feb 17.


Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.

Rohatgi R, Milenkovic L, Corcoran RB, Scott MP.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3196-201. doi: 10.1073/pnas.0813373106. Epub 2009 Feb 13.


Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.

Wang Y, Zhou Z, Walsh CT, McMahon AP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2623-8. doi: 10.1073/pnas.0812110106. Epub 2009 Feb 5.


The primary cilium at the crossroads of mammalian hedgehog signaling.

Wong SY, Reiter JF.

Curr Top Dev Biol. 2008;85:225-60. doi: 10.1016/S0070-2153(08)00809-0. Review.


The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation.

Yin Y, Bangs F, Paton IR, Prescott A, James J, Davey MG, Whitley P, Genikhovich G, Technau U, Burt DW, Tickle C.

Development. 2009 Feb;136(4):655-64. doi: 10.1242/dev.028464. Epub 2009 Jan 14.


Hedgehog signaling in development and cancer.

Jiang J, Hui CC.

Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010. Review.


Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control.

Molla-Herman A, Boularan C, Ghossoub R, Scott MG, Burtey A, Zarka M, Saunier S, Concordet JP, Marullo S, Benmerah A.

PLoS One. 2008;3(11):e3728. doi: 10.1371/journal.pone.0003728. Epub 2008 Nov 14.


C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A.

Development. 2008 Dec;135(24):4049-58. doi: 10.1242/dev.029835. Epub 2008 Nov 12.


Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.

Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A.

Dev Biol. 2009 Jan 1;325(1):225-37. doi: 10.1016/j.ydbio.2008.10.020. Epub 2008 Oct 29.


A paracrine requirement for hedgehog signalling in cancer.

Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ.

Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27.


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