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Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.

Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS.

Radiat Res. 2009 Aug;172(2):165-74. doi: 10.1667/RR1598.1.


Clinical radiation sensitivity with DNA repair disorders: an overview.

Pollard JM, Gatti RA.

Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1323-31. doi: 10.1016/j.ijrobp.2009.02.057. Review.


CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

Yun MH, Hiom K.

Nature. 2009 May 21;459(7245):460-3. doi: 10.1038/nature07955. Epub 2009 Apr 8.


Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro.

Prasad R, Longley MJ, Sharief FS, Hou EW, Copeland WC, Wilson SH.

Nucleic Acids Res. 2009 Apr;37(6):1868-77. doi: 10.1093/nar/gkp035. Epub 2009 Feb 2.


Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.

Zheng M, Morgan-Lappe SE, Yang J, Bockbrader KM, Pamarthy D, Thomas D, Fesik SW, Sun Y.

Cancer Res. 2008 Sep 15;68(18):7570-8. doi: 10.1158/0008-5472.CAN-08-0632.


Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.

Prevo R, Deutsch E, Sampson O, Diplexcito J, Cengel K, Harper J, O'Neill P, McKenna WG, Patel S, Bernhard EJ.

Cancer Res. 2008 Jul 15;68(14):5915-23. doi: 10.1158/0008-5472.CAN-08-0757.


Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer.

Brunner TB, Geiger M, Grabenbauer GG, Lang-Welzenbach M, Mantoni TS, Cavallaro A, Sauer R, Hohenberger W, McKenna WG.

J Clin Oncol. 2008 Jun 1;26(16):2699-706. doi: 10.1200/JCO.2007.15.2355.


Low-fidelity DNA synthesis by human DNA polymerase theta.

Arana ME, Seki M, Wood RD, Rogozin IB, Kunkel TA.

Nucleic Acids Res. 2008 Jun;36(11):3847-56. doi: 10.1093/nar/gkn310. Epub 2008 May 24.


Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.

Martomo SA, Saribasak H, Yokoi M, Hanaoka F, Gearhart PJ.

DNA Repair (Amst). 2008 Sep 1;7(9):1603-8. doi: 10.1016/j.dnarep.2008.04.002. Epub 2008 May 16.


A loss of function screen identifies nine new radiation susceptibility genes.

Sudo H, Tsuji AB, Sugyo A, Imai T, Saga T, Harada YN.

Biochem Biophys Res Commun. 2007 Dec 21;364(3):695-701. Epub 2007 Oct 22.


Clonogenic assay of cells in vitro.

Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C.

Nat Protoc. 2006;1(5):2315-9.


Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.

Chou DM, Elledge SJ.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18143-7. Epub 2006 Nov 20.


Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.

Yoshimura M, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S.

Mol Cell. 2006 Oct 6;24(1):115-25.


Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes.

Masuda K, Ouchida R, Hikida M, Nakayama M, Ohara O, Kurosaki T, O-Wang J.

DNA Repair (Amst). 2006 Nov 8;5(11):1384-91. Epub 2006 Aug 4.


Analysis of cell-based RNAi screens.

Boutros M, BrĂ¡s LP, Huber W.

Genome Biol. 2006;7(7):R66.


Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.

Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK.

N Engl J Med. 2006 Feb 9;354(6):567-78.


The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.

Zan H, Shima N, Xu Z, Al-Qahtani A, Evinger Iii AJ, Zhong Y, Schimenti JC, Casali P.

EMBO J. 2005 Nov 2;24(21):3757-69. Epub 2005 Oct 13.


Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.

Kim IA, Bae SS, Fernandes A, Wu J, Muschel RJ, McKenna WG, Birnbaum MJ, Bernhard EJ.

Cancer Res. 2005 Sep 1;65(17):7902-10.


ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.

McManus KJ, Hendzel MJ.

Mol Biol Cell. 2005 Oct;16(10):5013-25. Epub 2005 Jul 19.


The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death.

Trivedi RN, Almeida KH, Fornsaglio JL, Schamus S, Sobol RW.

Cancer Res. 2005 Jul 15;65(14):6394-400.

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