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Items: 17

1.

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation.

Chen Y, Smanski MJ, Shen B.

Appl Microbiol Biotechnol. 2010 Mar;86(1):19-25. doi: 10.1007/s00253-009-2428-3. Epub 2010 Jan 21. Review.

2.

Total synthesis of platensimycin and related natural products.

Nicolaou KC, Li A, Edmonds DJ, Tria GS, Ellery SP.

J Am Chem Soc. 2009 Nov 25;131(46):16905-18. doi: 10.1021/ja9068003.

3.

Isoplatensimycin: Synthesis and biological evaluation.

Jang KP, Kim CH, Na SW, Kim H, Kang H, Lee E.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4601-2. doi: 10.1016/j.bmcl.2009.06.092. Epub 2009 Jun 27.

PMID:
19604693
4.

Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.

Singh SB, Ondeyka JG, Herath KB, Zhang C, Jayasuriya H, Zink DL, Parthasarathy G, Becker JW, Wang J, Soisson SM.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4756-9. doi: 10.1016/j.bmcl.2009.06.061. Epub 2009 Jun 17.

PMID:
19581087
5.

Synthesis and biological evaluation of platensimycin analogs.

Shen HC, Ding FX, Singh SB, Parthasarathy G, Soisson SM, Ha SN, Chen X, Kodali S, Wang J, Dorso K, Tata JR, Hammond ML, Maccoss M, Colletti SL.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1623-7. doi: 10.1016/j.bmcl.2009.02.006. Epub 2009 Feb 7.

PMID:
19233644
6.

Efforts towards the identification of simpler platensimycin analogues--the total synthesis of oxazinidinyl platensimycin.

Wang J, Lee V, Sintim HO.

Chemistry. 2009;15(12):2747-50. doi: 10.1002/chem.200802568.

PMID:
19212990
7.

Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin.

Smanski MJ, Peterson RM, Rajski SR, Shen B.

Antimicrob Agents Chemother. 2009 Apr;53(4):1299-304. doi: 10.1128/AAC.01358-08. Epub 2009 Jan 21.

8.

Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis.

Zhang C, Ondeyka J, Zink DL, Burgess B, Wang J, Singh SB.

Chem Commun (Camb). 2008 Oct 28;(40):5034-6. doi: 10.1039/b810113b. Epub 2008 Sep 5.

PMID:
18931777
9.

Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.

Nicolaou KC, Stepan AF, Lister T, Li A, Montero A, Tria GS, Turner CI, Tang Y, Wang J, Denton RM, Edmonds DJ.

J Am Chem Soc. 2008 Oct 1;130(39):13110-9. doi: 10.1021/ja8044376. Epub 2008 Sep 5.

10.

Structure and semisynthesis of platensimide A, produced by Streptomyces platensis.

Herath KB, Zhang C, Jayasuriya H, Ondeyka JG, Zink DL, Burgess B, Wang J, Singh SB.

Org Lett. 2008 May 1;10(9):1699-702. doi: 10.1021/ol800251v. Epub 2008 Apr 8. Erratum in: Org Lett. 2009 May 7;11(9):2043.

PMID:
18393511
11.

Total synthesis and antibacterial properties of carbaplatensimycin.

Nicolaou KC, Tang Y, Wang J, Stepan AF, Li A, Montero A.

J Am Chem Soc. 2007 Dec 5;129(48):14850-1. Epub 2007 Nov 8.

PMID:
17988130
12.

Adamantaplatensimycin: a bioactive analogue of platensimycin.

Nicolaou KC, Lister T, Denton RM, Montero A, Edmonds DJ.

Angew Chem Int Ed Engl. 2007;46(25):4712-4. No abstract available.

PMID:
17514775
13.

Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.

Jayasuriya H, Herath KB, Zhang C, Zink DL, Basilio A, Genilloud O, Diez MT, Vicente F, Gonzalez I, Salazar O, Pelaez F, Cummings R, Ha S, Wang J, Singh SB.

Angew Chem Int Ed Engl. 2007;46(25):4684-8. No abstract available.

PMID:
17487925
14.

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6. Epub 2007 Apr 24.

15.

Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.

Singh SB, Jayasuriya H, Ondeyka JG, Herath KB, Zhang C, Zink DL, Tsou NN, Ball RG, Basilio A, Genilloud O, Diez MT, Vicente F, Pelaez F, Young K, Wang J.

J Am Chem Soc. 2006 Sep 13;128(36):11916-20. Erratum in: J Am Chem Soc. 2006 Dec 6;128(48):15547.

PMID:
16953632
16.

Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB.

Nature. 2006 May 18;441(7091):358-61.

PMID:
16710421
17.

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.

Gust B, Challis GL, Fowler K, Kieser T, Chater KF.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1541-6. Epub 2003 Jan 31.

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