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Items: 1 to 20 of 67

1.

Usa1 functions as a scaffold of the HRD-ubiquitin ligase.

Horn SC, Hanna J, Hirsch C, Volkwein C, Sch├╝tz A, Heinemann U, Sommer T, Jarosch E.

Mol Cell. 2009 Dec 11;36(5):782-93. doi: 10.1016/j.molcel.2009.10.015.

2.

Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.

Carroll SM, Hampton RY.

J Biol Chem. 2010 Feb 19;285(8):5146-56. doi: 10.1074/jbc.M109.067876. Epub 2009 Nov 24.

3.

Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system.

Xie W, Kanehara K, Sayeed A, Ng DT.

Mol Biol Cell. 2009 Jul;20(14):3317-29. doi: 10.1091/mbc.E09-03-0231. Epub 2009 May 20.

4.

Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase.

Sato BK, Schulz D, Do PH, Hampton RY.

Mol Cell. 2009 Apr 24;34(2):212-22. doi: 10.1016/j.molcel.2009.03.010.

5.

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum.

Clerc S, Hirsch C, Oggier DM, Deprez P, Jakob C, Sommer T, Aebi M.

J Cell Biol. 2009 Jan 12;184(1):159-72. doi: 10.1083/jcb.200809198. Epub 2009 Jan 5.

6.

Defining the glycan destruction signal for endoplasmic reticulum-associated degradation.

Quan EM, Kamiya Y, Kamiya D, Denic V, Weibezahn J, Kato K, Weissman JS.

Mol Cell. 2008 Dec 26;32(6):870-7. doi: 10.1016/j.molcel.2008.11.017.

7.

One step at a time: endoplasmic reticulum-associated degradation.

Vembar SS, Brodsky JL.

Nat Rev Mol Cell Biol. 2008 Dec;9(12):944-57. doi: 10.1038/nrm2546. Epub 2008 Nov 12. Review.

8.

Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

Metzger MB, Maurer MJ, Dancy BM, Michaelis S.

J Biol Chem. 2008 Nov 21;283(47):32302-16. doi: 10.1074/jbc.M806424200. Epub 2008 Sep 23.

9.

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K.

J Biol Chem. 2008 Jul 25;283(30):20914-24. doi: 10.1074/jbc.M709336200. Epub 2008 May 23.

10.

The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum.

Nakatsukasa K, Brodsky JL.

Traffic. 2008 Jun;9(6):861-70. doi: 10.1111/j.1600-0854.2008.00729.x. Epub 2008 Feb 24. Review.

11.

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

Christianson JC, Shaler TA, Tyler RE, Kopito RR.

Nat Cell Biol. 2008 Mar;10(3):272-82. doi: 10.1038/ncb1689. Epub 2008 Feb 10.

12.

Derlin-1 facilitates the retro-translocation of cholera toxin.

Bernardi KM, Forster ML, Lencer WI, Tsai B.

Mol Biol Cell. 2008 Mar;19(3):877-84. Epub 2007 Dec 19.

13.

Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp.

Okuda-Shimizu Y, Hendershot LM.

Mol Cell. 2007 Nov 30;28(4):544-54.

14.

Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases.

Hosokawa N, You Z, Tremblay LO, Nagata K, Herscovics A.

Biochem Biophys Res Commun. 2007 Oct 26;362(3):626-32. Epub 2007 Aug 20.

PMID:
17727818
15.

Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.

Wahlman J, DeMartino GN, Skach WR, Bulleid NJ, Brodsky JL, Johnson AE.

Cell. 2007 Jun 1;129(5):943-55.

16.

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC.

Nat Chem Biol. 2007 Jun;3(6):331-8. Epub 2007 May 7.

17.

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

Mueller B, Lilley BN, Ploegh HL.

J Cell Biol. 2006 Oct 23;175(2):261-70. Epub 2006 Oct 16.

18.

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

Olivari S, Cali T, Salo KE, Paganetti P, Ruddock LW, Molinari M.

Biochem Biophys Res Commun. 2006 Nov 3;349(4):1278-84. Epub 2006 Sep 12.

PMID:
16987498
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