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Items: 1 to 20 of 43


TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

Huppa JB, Axmann M, Mörtelmaier MA, Lillemeier BF, Newell EW, Brameshuber M, Klein LO, Schütz GJ, Davis MM.

Nature. 2010 Feb 18;463(7283):963-7. doi: 10.1038/nature08746.


Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon.

Martínez-Martín N, Risueño RM, Morreale A, Zaldívar I, Fernández-Arenas E, Herranz F, Ortiz AR, Alarcón B.

Sci Signal. 2009 Aug 11;2(83):ra43. doi: 10.1126/scisignal.2000402.


Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J.

Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21.


Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.

Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH.

Immunity. 2008 Jul 18;29(1):90-100. doi: 10.1016/j.immuni.2008.04.022. Epub 2008 Jun 26.


Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.

Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA.

Nat Immunol. 2008 Jun;9(6):658-66. doi: 10.1038/ni.1611. Epub 2008 May 11.


Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds.

Roessler CG, Hall BM, Anderson WJ, Ingram WM, Roberts SA, Montfort WR, Cordes MH.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2343-8. doi: 10.1073/pnas.0711589105. Epub 2008 Jan 28.


Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.

Huse M, Klein LO, Girvin AT, Faraj JM, Li QJ, Kuhns MS, Davis MM.

Immunity. 2007 Jul;27(1):76-88. Epub 2007 Jul 12.


Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

Minguet S, Swamy M, Alarcón B, Luescher IF, Schamel WW.

Immunity. 2007 Jan;26(1):43-54. Epub 2006 Dec 21.


The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.

Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW.

Cell. 2006 Oct 20;127(2):355-68.


The TCR C beta FG loop regulates alpha beta T cell development.

Touma M, Chang HC, Sasada T, Handley M, Clayton LK, Reinherz EL.

J Immunol. 2006 Jun 1;176(11):6812-23.


Evolution of protein fold in the presence of functional constraints.

Andreeva A, Murzin AG.

Curr Opin Struct Biol. 2006 Jun;16(3):399-408. Epub 2006 May 2. Review.


Deconstructing the form and function of the TCR/CD3 complex.

Kuhns MS, Davis MM, Garcia KC.

Immunity. 2006 Feb;24(2):133-9. Review.


T cells use two directionally distinct pathways for cytokine secretion.

Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM.

Nat Immunol. 2006 Mar;7(3):247-55. Epub 2006 Jan 29.


Stoichiometry of the murine gammadelta T cell receptor.

Hayes SM, Love PE.

J Exp Med. 2006 Jan 23;203(1):47-52. Epub 2006 Jan 17.


Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.

Yamasaki S, Ishikawa E, Sakuma M, Ogata K, Sakata-Sogawa K, Hiroshima M, Wiest DL, Tokunaga M, Saito T.

Nat Immunol. 2006 Jan;7(1):67-75. Epub 2005 Dec 4.


Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

Yokosuka T, Sakata-Sogawa K, Kobayashi W, Hiroshima M, Hashimoto-Tane A, Tokunaga M, Dustin ML, Saito T.

Nat Immunol. 2005 Dec;6(12):1253-62. Epub 2005 Nov 6.


Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.

Campi G, Varma R, Dustin ML.

J Exp Med. 2005 Oct 17;202(8):1031-6. Epub 2005 Oct 10.

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