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Items: 1 to 20 of 42

1.

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.

Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y, Yin Y, Koff A, Ma L, Zhou P.

Mol Cell. 2009 May 14;34(4):451-60. doi: 10.1016/j.molcel.2009.04.020.

2.

Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling.

López-Lago MA, Okada T, Murillo MM, Socci N, Giancotti FG.

Mol Cell Biol. 2009 Aug;29(15):4235-49. doi: 10.1128/MCB.01578-08. Epub 2009 May 18.

3.

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.

James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V.

Mol Cell Biol. 2009 Aug;29(15):4250-61. doi: 10.1128/MCB.01581-08. Epub 2009 May 18.

4.

Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex.

McClatchey AI, Fehon RG.

Trends Cell Biol. 2009 May;19(5):198-206. doi: 10.1016/j.tcb.2009.02.006. Epub 2009 Apr 1. Review.

5.

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

Maddika S, Chen J.

Nat Cell Biol. 2009 Apr;11(4):409-19. doi: 10.1038/ncb1848. Epub 2009 Mar 15.

6.

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

Lallemand D, Manent J, Couvelard A, Watilliaux A, Siena M, Chareyre F, Lampin A, Niwa-Kawakita M, Kalamarides M, Giovannini M.

Oncogene. 2009 Feb 12;28(6):854-65. doi: 10.1038/onc.2008.427. Epub 2008 Nov 24.

PMID:
19029950
7.

Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.

McCall CM, Miliani de Marval PL, Chastain PD 2nd, Jackson SC, He YJ, Kotake Y, Cook JG, Xiong Y.

Mol Cell Biol. 2008 Sep;28(18):5621-33. doi: 10.1128/MCB.00232-08. Epub 2008 Jul 7.

8.

Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma.

Ammoun S, Flaiz C, Ristic N, Schuldt J, Hanemann CO.

Cancer Res. 2008 Jul 1;68(13):5236-45. doi: 10.1158/0008-5472.CAN-07-5849.

9.

VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.

Huang J, Chen J.

Oncogene. 2008 Jul 3;27(29):4056-64. doi: 10.1038/onc.2008.44. Epub 2008 Mar 10.

PMID:
18332868
10.

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D.

Mol Cell. 2008 Jan 18;29(1):9-22. doi: 10.1016/j.molcel.2007.11.031.

11.

Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.

Tang X, Jang SW, Wang X, Liu Z, Bahr SM, Sun SY, Brat D, Gutmann DH, Ye K.

Nat Cell Biol. 2007 Oct;9(10):1199-207. Epub 2007 Sep 23.

PMID:
17891137
12.

Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression.

Pylayeva Y, Guo W, Giancotti FG.

Methods Enzymol. 2007;426:439-61. Review.

PMID:
17697895
13.
14.

Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.

Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11778-83. Epub 2007 Jul 3.

15.

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

Lee J, Zhou P.

Mol Cell. 2007 Jun 22;26(6):775-80. Review.

16.

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin.

Curto M, Cole BK, Lallemand D, Liu CH, McClatchey AI.

J Cell Biol. 2007 Jun 4;177(5):893-903.

17.

Shedding light on Merlin's wizardry.

Okada T, You L, Giancotti FG.

Trends Cell Biol. 2007 May;17(5):222-9. Epub 2007 Apr 17. Review. Erratum in: Trends Cell Biol. 2008 Jan;18(1):11.

PMID:
17442573
18.

Hippo signaling in organ size control.

Pan D.

Genes Dev. 2007 Apr 15;21(8):886-97. Review.

19.

Ubiquitin proteasome system (UPS): what can chromatin do for you?

O'Connell BC, Harper JW.

Curr Opin Cell Biol. 2007 Apr;19(2):206-14. Epub 2007 Feb 20. Review.

PMID:
17314036
20.

Wnt/beta-catenin signaling in development and disease.

Clevers H.

Cell. 2006 Nov 3;127(3):469-80. Review.

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