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PECAM-1 is a critical mediator of atherosclerosis.

Stevens HY, Melchior B, Bell KS, Yun S, Yeh JC, Frangos JA.

Dis Model Mech. 2008 Sep-Oct;1(2-3):175-81; discussion 179. doi: 10.1242/dmm.000547. Epub 2008 Sep 18.


Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice.

Harry BL, Sanders JM, Feaver RE, Lansey M, Deem TL, Zarbock A, Bruce AC, Pryor AW, Gelfand BD, Blackman BR, Schwartz MA, Ley K.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2003-8. doi: 10.1161/ATVBAHA.108.164707. Epub 2008 Aug 7.


Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice.

Goel R, Schrank BR, Arora S, Boylan B, Fleming B, Miura H, Newman PJ, Molthen RC, Newman DK.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1996-2002. doi: 10.1161/ATVBAHA.108.172270. Epub 2008 Jul 31.


PECAM-1 ligation negatively regulates TLR4 signaling in macrophages.

Rui Y, Liu X, Li N, Jiang Y, Chen G, Cao X, Wang J.

J Immunol. 2007 Dec 1;179(11):7344-51.


The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis.

Goel R, Boylan B, Gruman L, Newman PJ, North PE, Newman DK.

Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1205-14. Epub 2007 Oct 11.


The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).

Sachs UJ, Andrei-Selmer CL, Maniar A, Weiss T, Paddock C, Orlova VV, Choi EY, Newman PJ, Preissner KT, Chavakis T, Santoso S.

J Biol Chem. 2007 Aug 10;282(32):23603-12. Epub 2007 Jun 19.


The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy.

Bergom C, Goel R, Paddock C, Gao C, Newman DK, Matsuyama S, Newman PJ.

Cancer Biol Ther. 2006 Dec;5(12):1699-707. Epub 2006 Dec 30.


Platelet PECAM-1 inhibits thrombus formation in vivo.

Falati S, Patil S, Gross PL, Stapleton M, Merrill-Skoloff G, Barrett NE, Pixton KL, Weiler H, Cooley B, Newman DK, Newman PJ, Furie BC, Furie B, Gibbins JM.

Blood. 2006 Jan 15;107(2):535-41. Epub 2005 Sep 15.


Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice.

Liu Y, Bubolz AH, Shi Y, Newman PJ, Newman DK, Gutterman DD.

Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R57-65. Epub 2005 Sep 15.


A mechanosensory complex that mediates the endothelial cell response to fluid shear stress.

Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H, Schwartz MA.

Nature. 2005 Sep 15;437(7057):426-31.


The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritis.

Wong MX, Hayball JD, Hogarth PM, Jackson DE.

J Clin Immunol. 2005 Jan;25(1):19-28.


Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice.

Carrithers M, Tandon S, Canosa S, Michaud M, Graesser D, Madri JA.

Am J Pathol. 2005 Jan;166(1):185-96.


Endothelial cell PECAM-1 confers protection against endotoxic shock.

Maas M, Stapleton M, Bergom C, Mattson DL, Newman DK, Newman PJ.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H159-64. Epub 2004 Aug 19.


Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1.

Tada Y, Koarada S, Morito F, Ushiyama O, Haruta Y, Kanegae F, Ohta A, Ho A, Mak TW, Nagasawa K.

Arthritis Rheum. 2003 Nov;48(11):3280-90.


PMN transendothelial migration decreases nuclear NFkappaB in IL-1beta-activated endothelial cells: role of PECAM-1.

Cepinskas G, Savickiene J, Ionescu CV, Kvietys PR.

J Cell Biol. 2003 May 12;161(3):641-51.


Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology.

Newman PJ, Newman DK.

Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):953-64. Epub 2003 Apr 10. Review.


Leukocyte-endothelial cell interactions in the inflammatory response.

Muller WA.

Lab Invest. 2002 May;82(5):521-33. Review. No abstract available.


Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice.

Graesser D, Solowiej A, Bruckner M, Osterweil E, Juedes A, Davis S, Ruddle NH, Engelhardt B, Madri JA.

J Clin Invest. 2002 Feb;109(3):383-92.

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