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Items: 1 to 20 of 43

1.

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.

Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA.

Aging (Albany NY). 2009 Jun 3;1(6):515-28.

2.

Inhibition of S6K by resveratrol: in search of the purpose.

Blagosklonny MV.

Aging (Albany NY). 2009 Jun 29;1(6):511-4. No abstract available.

3.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA.

Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221.

4.

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence.

Demidenko ZN, Blagosklonny MV.

Cell Cycle. 2009 Jun 15;8(12):1901-4.

PMID:
19471118
5.

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J.

Nature. 2009 Apr 23;458(7241):1056-60. doi: 10.1038/nature07813.

6.

SirT1 regulates energy metabolism and response to caloric restriction in mice.

Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J, Evans M, Harper ME, McBurney MW.

PLoS One. 2008 Mar 12;3(3):e1759. doi: 10.1371/journal.pone.0001759.

7.

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.

Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3374-9. doi: 10.1073/pnas.0712145105.

8.

SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity.

Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H.

Mol Biol Cell. 2008 Mar;19(3):1210-9. doi: 10.1091/mbc.E07-09-0965.

9.

Regulation of macroautophagy by mTOR and Beclin 1 complexes.

Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P.

Biochimie. 2008 Feb;90(2):313-23. Review.

PMID:
17928127
10.
11.

SIRT1 transgenic mice show phenotypes resembling calorie restriction.

Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L.

Aging Cell. 2007 Dec;6(6):759-67.

12.

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription.

Ghosh HS, Spencer JV, Ng B, McBurney MW, Robbins PD.

Biochem J. 2007 Nov 15;408(1):105-11.

13.

Cytoplasm-localized SIRT1 enhances apoptosis.

Jin Q, Yan T, Ge X, Sun C, Shi X, Zhai Q.

J Cell Physiol. 2007 Oct;213(1):88-97.

PMID:
17516504
14.

Resveratrol stimulates AMP kinase activity in neurons.

Dasgupta B, Milbrandt J.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7217-22.

15.

SIR2: a potential target for calorie restriction mimetics.

Chen D, Guarente L.

Trends Mol Med. 2007 Feb;13(2):64-71. Review.

PMID:
17207661
16.

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1.

Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y.

J Biol Chem. 2007 Mar 2;282(9):6823-32.

17.

DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse.

Sommer M, Poliak N, Upadhyay S, Ratovitski E, Nelkin BD, Donehower LA, Sidransky D.

Cell Cycle. 2006 Sep;5(17):2005-11.

PMID:
16940753
18.

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L.

Cell. 2006 Jun 16;125(6):1165-77.

19.

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.

Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM.

J Biol Chem. 2006 Aug 4;281(31):21745-54.

20.
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