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Items: 1 to 20 of 45

1.

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.

Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC.

Nature. 2009 Nov 5;462(7269):108-12. doi: 10.1038/nature08460. Epub 2009 Oct 21.

2.

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC; International Schizophrenia Consortium., Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ.

PLoS Genet. 2009 Jun;5(6):e1000534. doi: 10.1371/journal.pgen.1000534. Epub 2009 Jun 26.

3.

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.

Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan VE, Zakowski MF, Rusch V, Pao W, Gerald W, Ladanyi M.

Oncogene. 2009 Aug 6;28(31):2773-83. doi: 10.1038/onc.2009.135. Epub 2009 Jun 15.

4.

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG.

Cell. 2009 May 29;137(5):821-34. doi: 10.1016/j.cell.2009.03.017.

5.

The cancer genome.

Stratton MR, Campbell PJ, Futreal PA.

Nature. 2009 Apr 9;458(7239):719-24. doi: 10.1038/nature07943. Review.

6.

Linking somatic genetic alterations in cancer to therapeutics.

Stuart D, Sellers WR.

Curr Opin Cell Biol. 2009 Apr;21(2):304-10. doi: 10.1016/j.ceb.2009.02.001. Epub 2009 Mar 26. Review.

PMID:
19328671
7.

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family.

Beverly LJ, Varmus HE.

Oncogene. 2009 Mar 5;28(9):1274-9. doi: 10.1038/onc.2008.466. Epub 2009 Jan 12.

8.

Highly parallel identification of essential genes in cancer cells.

Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, Piqani B, Li C, Golub TR, Meyerson M, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20380-5. doi: 10.1073/pnas.0810485105. Epub 2008 Dec 17.

9.

Human embryonic stem cells reveal recurrent genomic instability at 20q11.21.

Lefort N, Feyeux M, Bas C, Féraud O, Bennaceur-Griscelli A, Tachdjian G, Peschanski M, Perrier AL.

Nat Biotechnol. 2008 Dec;26(12):1364-6. doi: 10.1038/nbt.1509. Epub 2008 Nov 23.

PMID:
19029913
10.

Recurrent chromosomal abnormalities in human embryonic stem cells.

Spits C, Mateizel I, Geens M, Mertzanidou A, Staessen C, Vandeskelde Y, Van der Elst J, Liebaers I, Sermon K.

Nat Biotechnol. 2008 Dec;26(12):1361-3. doi: 10.1038/nbt.1510. Epub 2008 Nov 23.

PMID:
19029912
11.

Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Cancer Genome Atlas Research Network..

Nature. 2008 Oct 23;455(7216):1061-8. doi: 10.1038/nature07385. Epub 2008 Sep 4. Erratum in: Nature. 2013 Feb 28;494(7438):506.

12.

BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.

Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH, Relling MV, Shurtleff SA, Downing JR.

Nature. 2008 May 1;453(7191):110-4. doi: 10.1038/nature06866. Epub 2008 Apr 13.

PMID:
18408710
13.

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.

Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L.

Cancer Cell. 2008 Apr;13(4):355-64. doi: 10.1016/j.ccr.2008.02.010.

14.

Modeling genomic diversity and tumor dependency in malignant melanoma.

Lin WM, Baker AC, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA.

Cancer Res. 2008 Feb 1;68(3):664-73. doi: 10.1158/0008-5472.CAN-07-2615.

15.

Diagnosing and exploiting cancer's addiction to blocks in apoptosis.

Letai AG.

Nat Rev Cancer. 2008 Feb;8(2):121-32. doi: 10.1038/nrc2297. Review.

PMID:
18202696
17.

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.

Beroukhim R, Getz G, Nghiemphu L, Barretina J, Hsueh T, Linhart D, Vivanco I, Lee JC, Huang JH, Alexander S, Du J, Kau T, Thomas RK, Shah K, Soto H, Perner S, Prensner J, Debiasi RM, Demichelis F, Hatton C, Rubin MA, Garraway LA, Nelson SF, Liau L, Mischel PS, Cloughesy TF, Meyerson M, Golub TA, Lander ES, Mellinghoff IK, Sellers WR.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20007-12. Epub 2007 Dec 6.

18.

Characterizing the cancer genome in lung adenocarcinoma.

Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M.

Nature. 2007 Dec 6;450(7171):893-8. Epub 2007 Nov 4.

19.

Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer.

Kendall J, Liu Q, Bakleh A, Krasnitz A, Nguyen KC, Lakshmi B, Gerald WL, Powers S, Mu D.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16663-8. Epub 2007 Oct 9.

20.

Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.

Cell. 2007 Jun 15;129(6):1065-79.

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