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20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.

Chen Y, Falck JR, Tuniki VR, Campbell WB.

J Pharmacol Exp Ther. 2009 Dec;331(3):1137-45. doi: 10.1124/jpet.109.157818.


Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice.

Sodhi K, Inoue K, Gotlinger KH, Canestraro M, Vanella L, Kim DH, Manthati VL, Koduru SR, Falck JR, Schwartzman ML, Abraham NG.

J Pharmacol Exp Ther. 2009 Dec;331(3):906-16. doi: 10.1124/jpet.109.157545.


14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi XY, Goldman DH, Morisseau C, Hammock BD, Campbell WB.

J Med Chem. 2009 Aug 27;52(16):5069-75. doi: 10.1021/jm900634w.


The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.

Yang S, Wei S, Pozzi A, Capdevila JH.

Arch Biochem Biophys. 2009 Sep;489(1-2):82-91. doi: 10.1016/


Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog.

Gross GJ, Gauthier KM, Moore J, Campbell WB, Falck JR, Nithipatikom K.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H47-52. doi: 10.1152/ajpheart.01084.2008.


Arachidonic acid cytochrome P450 epoxygenase pathway.

Spector AA.

J Lipid Res. 2009 Apr;50 Suppl:S52-6. doi: 10.1194/jlr.R800038-JLR200. Review.


Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice.

Hercule HC, Schunck WH, Gross V, Seringer J, Leung FP, Weldon SM, da Costa Goncalves ACh, Huang Y, Luft FC, Gollasch M.

Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):54-60. doi: 10.1161/ATVBAHA.108.171298.


Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.

Nayeem MA, Poloyac SM, Falck JR, Zeldin DC, Ledent C, Ponnoth DS, Ansari HR, Mustafa SJ.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2068-78. doi: 10.1152/ajpheart.01333.2007.


Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ.

Stroke. 2008 Jul;39(7):2073-8. doi: 10.1161/STROKEAHA.107.508325.


Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.

Imig JD, Dimitropoulou C, Reddy DS, White RE, Falck JR.

Microcirculation. 2008 Feb;15(2):137-50. doi: 10.1080/10739680701456960.


Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids.

Yan G, Chen S, You B, Sun J.

Cardiovasc Res. 2008 May 1;78(2):308-14. doi: 10.1093/cvr/cvn006.


Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.

Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL.

Drug Metab Dispos. 2007 Jul;35(7):1126-34.


Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.

Yang W, Holmes BB, Gopal VR, Kishore RV, Sangras B, Yi XY, Falck JR, Campbell WB.

J Pharmacol Exp Ther. 2007 Jun;321(3):1023-31.


Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.

Dimitropoulou C, West L, Field MB, White RE, Reddy LM, Falck JR, Imig JD.

Prostaglandins Other Lipid Mediat. 2007 Feb;83(1-2):50-61.


Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors.

Imig JD.

Cardiovasc Drug Rev. 2006 Summer;24(2):169-88. Review.


Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC.

Sun P, Lin DH, Wang T, Babilonia E, Wang Z, Jin Y, Kemp R, Nasjletti A, Wang WH.

Am J Physiol Renal Physiol. 2006 Dec;291(6):F1192-200.


Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase.

Sacerdoti D, Bolognesi M, Di Pascoli M, Gatta A, McGiff JC, Schwartzman ML, Abraham NG.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1999-2002.


Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E Jr, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH.

J Clin Invest. 2006 Jun;116(6):1696-702.


Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.

Carroll MA, Doumad AB, Li J, Cheng MK, Falck JR, McGiff JC.

Am J Physiol Renal Physiol. 2006 Jul;291(1):F155-61.


Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.

Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC.

FASEB J. 2006 Mar;20(3):539-41.

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