Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 50

1.

The role of sirtuins in the control of metabolic homeostasis.

Yu J, Auwerx J.

Ann N Y Acad Sci. 2009 Sep;1173 Suppl 1:E10-9. doi: 10.1111/j.1749-6632.2009.04952.x. Review.

2.

Recent progress in the biology and physiology of sirtuins.

Finkel T, Deng CX, Mostoslavsky R.

Nature. 2009 Jul 30;460(7255):587-91. doi: 10.1038/nature08197. Review.

3.

HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.

Chen D, Thomas EL, Kapahi P.

PLoS Genet. 2009 May;5(5):e1000486. doi: 10.1371/journal.pgen.1000486. Epub 2009 May 22.

4.

Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Vander Heiden MG, Cantley LC, Thompson CB.

Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809. Review.

5.

Bmi1 regulates mitochondrial function and the DNA damage response pathway.

Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T.

Nature. 2009 May 21;459(7245):387-392. doi: 10.1038/nature08040. Epub 2009 Apr 29.

6.

Proteasomal regulation of the hypoxic response modulates aging in C. elegans.

Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M.

Science. 2009 May 29;324(5931):1196-8. doi: 10.1126/science.1173507. Epub 2009 Apr 16.

7.

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J.

Nature. 2009 Apr 23;458(7241):1056-60. doi: 10.1038/nature07813.

8.

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.

Xia X, Lemieux ME, Li W, Carroll JS, Brown M, Liu XS, Kung AL.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4260-5. doi: 10.1073/pnas.0810067106. Epub 2009 Mar 2.

9.

Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones.

Barzilai N, Bartke A.

J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):187-91. doi: 10.1093/gerona/gln061. Epub 2009 Feb 19. Review.

10.

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF.

Cell. 2009 Jan 9;136(1):62-74. doi: 10.1016/j.cell.2008.10.052.

11.

Oxygen sensors at the crossroad of metabolism.

Aragonés J, Fraisl P, Baes M, Carmeliet P.

Cell Metab. 2009 Jan 7;9(1):11-22. doi: 10.1016/j.cmet.2008.10.001. Review.

12.

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O.

Mol Cell. 2008 Dec 26;32(6):838-48. doi: 10.1016/j.molcel.2008.12.004.

13.

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury.

Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M, Farrell L, Asnani A, Cyrille M, Ramanathan A, Shaham O, Berriz G, Lowry PA, Palacios IF, Taşan M, Roth FP, Min J, Baumgartner C, Keshishian H, Addona T, Mootha VK, Rosenzweig A, Carr SA, Fifer MA, Sabatine MS, Gerszten RE.

J Clin Invest. 2008 Oct;118(10):3503-12. doi: 10.1172/JCI35111.

14.

Transcription regulation through promoter-proximal pausing of RNA polymerase II.

Core LJ, Lis JT.

Science. 2008 Mar 28;319(5871):1791-2. doi: 10.1126/science.1150843.

15.

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF.

Nature. 2008 Mar 27;452(7186):492-6. doi: 10.1038/nature06736. Epub 2008 Mar 12.

16.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.

17.

CDK8 is a stimulus-specific positive coregulator of p53 target genes.

Donner AJ, Szostek S, Hoover JM, Espinosa JM.

Mol Cell. 2007 Jul 6;27(1):121-33.

18.

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.

Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL.

Cancer Cell. 2007 May;11(5):407-20.

19.

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis.

Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL, Simon MC, Thompson CB.

Genes Dev. 2007 May 1;21(9):1037-49. Epub 2007 Apr 16.

20.

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.

Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL.

Cell. 2007 Apr 6;129(1):111-22.

Supplemental Content

Support Center