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Items: 1 to 20 of 32

1.

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.

Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, Khuri FR, Sun SY.

Cancer Res. 2009 Dec 1;69(23):8967-76. doi: 10.1158/0008-5472.CAN-09-2190. Epub 2009 Nov 17.

PMID:
19920197
2.

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells.

Li HF, Kim JS, Waldman T.

Radiat Oncol. 2009 Oct 14;4:43. doi: 10.1186/1748-717X-4-43.

PMID:
19828040
3.

The increasing complexity of the cancer stem cell paradigm.

Rosen JM, Jordan CT.

Science. 2009 Jun 26;324(5935):1670-3. doi: 10.1126/science.1171837. Review.

PMID:
19556499
4.

Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.

Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS.

PLoS Biol. 2009 Jun 2;7(6):e1000121. doi: 10.1371/journal.pbio.1000121. Epub 2009 Jun 2.

PMID:
19492080
5.

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR.

Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK.

Cancer Res. 2009 Apr 15;69(8):3256-61. doi: 10.1158/0008-5472.CAN-08-4055. Epub 2009 Apr 7. Erratum in: Cancer Res. 2015 May 1;75(9):1922.

PMID:
19351834
6.

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.

Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC.

Cell Stem Cell. 2009 Mar 6;4(3):226-35. doi: 10.1016/j.stem.2009.01.007.

PMID:
19265662
7.

Radiation resistance of breast cancer stem cells: understanding the clinical framework.

Debeb BG, Xu W, Woodward WA.

J Mammary Gland Biol Neoplasia. 2009 Mar;14(1):11-7. doi: 10.1007/s10911-009-9114-z. Epub 2009 Feb 28. Review.

PMID:
19252973
8.

Association of reactive oxygen species levels and radioresistance in cancer stem cells.

Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF.

Nature. 2009 Apr 9;458(7239):780-3. doi: 10.1038/nature07733.

PMID:
19194462
9.

Wnt signaling and stem cell control.

Nusse R, Fuerer C, Ching W, Harnish K, Logan C, Zeng A, ten Berge D, Kalani Y.

Cold Spring Harb Symp Quant Biol. 2008;73:59-66. doi: 10.1101/sqb.2008.73.035. Epub 2008 Nov 21. Review.

PMID:
19028988
10.

Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours.

Veeck J, Bektas N, Hartmann A, Kristiansen G, Heindrichs U, Knüchel R, Dahl E.

Breast Cancer Res. 2008;10(5):R82. doi: 10.1186/bcr2151. Epub 2008 Sep 30.

PMID:
18826564
11.

Identification of tumor-initiating cells in a p53-null mouse model of breast cancer.

Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM.

Cancer Res. 2008 Jun 15;68(12):4674-82. doi: 10.1158/0008-5472.CAN-07-6353.

PMID:
18559513
12.

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.

Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC.

J Natl Cancer Inst. 2008 May 7;100(9):672-9. doi: 10.1093/jnci/djn123. Epub 2008 Apr 29.

PMID:
18445819
13.

Tumor growth need not be driven by rare cancer stem cells.

Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A.

Science. 2007 Jul 20;317(5836):337.

PMID:
17641192
14.

Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation.

Kao GD, Jiang Z, Fernandes AM, Gupta AK, Maity A.

J Biol Chem. 2007 Jul 20;282(29):21206-12. Epub 2007 May 18.

PMID:
17513297
15.

Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.

Jiang Z, Pore N, Cerniglia GJ, Mick R, Georgescu MM, Bernhard EJ, Hahn SM, Gupta AK, Maity A.

Cancer Res. 2007 May 1;67(9):4467-73.

PMID:
17483362
16.

PTEN-deficient intestinal stem cells initiate intestinal polyposis.

He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L.

Nat Genet. 2007 Feb;39(2):189-98. Epub 2007 Jan 21.

PMID:
17237784
17.

Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line.

Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro MP, Buchholz TA, Rosen JM.

J Cell Sci. 2007 Feb 1;120(Pt 3):468-77. Epub 2007 Jan 16.

PMID:
17227796
18.

WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells.

Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):618-23. Epub 2007 Jan 3. Erratum in: Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7307.

PMID:
17202265
19.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN.

Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18.

PMID:
17051156
20.

Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells.

de la Peña L, Burgan WE, Carter DJ, Hollingshead MG, Satyamitra M, Camphausen K, Tofilon PJ.

Mol Cancer Ther. 2006 Jun;5(6):1504-10.

PMID:
16818509

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