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Items: 1 to 20 of 40

1.

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.

Sato T, Nakashima A, Guo L, Tamanoi F.

J Biol Chem. 2009 May 8;284(19):12783-91. doi: 10.1074/jbc.M809207200. Epub 2009 Mar 19.

2.

Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.

Zhang L, Kimball SR, Jefferson LS, Shenberger JS.

Free Radic Biol Med. 2009 Jun 1;46(11):1500-9. doi: 10.1016/j.freeradbiomed.2009.03.001. Epub 2009 Mar 10.

3.

PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells.

Zhang F, Beharry ZM, Harris TE, Lilly MB, Smith CD, Mahajan S, Kraft AS.

Cancer Biol Ther. 2009 May;8(9):846-53. Epub 2009 May 18.

PMID:
19276681
4.

Akt-dependent and -independent mechanisms of mTOR regulation in cancer.

Memmott RM, Dennis PA.

Cell Signal. 2009 May;21(5):656-64. doi: 10.1016/j.cellsig.2009.01.004. Epub 2009 Jan 7. Review.

5.

Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice.

Miller AM, Brestoff JR, Phelps CB, Berk EZ, Reynolds TH 4th.

Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1431-8. doi: 10.1152/ajpregu.90428.2008. Epub 2008 Sep 3. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2011 Aug;301(2):R558. Dosage error in article text.

6.

Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. doi: 10.1152/ajpendo.90645.2008. Epub 2008 Sep 2. Review.

7.

Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase.

Hong-Brown LQ, Brown CR, Huber DS, Lang CH.

J Cell Biochem. 2008 Oct 15;105(3):814-23. doi: 10.1002/jcb.21882.

8.

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ.

Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003.

9.

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.

Wang L, Harris TE, Lawrence JC Jr.

J Biol Chem. 2008 Jun 6;283(23):15619-27. doi: 10.1074/jbc.M800723200. Epub 2008 Mar 27.

10.

ETOH inhibits embryonic neural stem/precursor cell proliferation via PLD signaling.

Fujita Y, Hiroyama M, Sanbe A, Yamauchi J, Murase S, Tanoue A.

Biochem Biophys Res Commun. 2008 May 23;370(1):169-73. doi: 10.1016/j.bbrc.2008.03.060. Epub 2008 Mar 20.

PMID:
18358832
11.

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

Fonseca BD, Lee VH, Proud CG.

Biochem J. 2008 Apr 1;411(1):141-9. doi: 10.1042/BJ20071001.

PMID:
18215133
12.

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.

Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19011-6. Epub 2007 Nov 15.

13.

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.

Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG.

J Biol Chem. 2007 Aug 24;282(34):24514-24. Epub 2007 Jun 29.

14.

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.

Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.

J Biol Chem. 2007 Jul 13;282(28):20329-39. Epub 2007 May 21.

15.

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.

Wang L, Harris TE, Roth RA, Lawrence JC Jr.

J Biol Chem. 2007 Jul 6;282(27):20036-44. Epub 2007 May 17.

16.
17.

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.

Mol Cell. 2007 Mar 23;25(6):903-15.

18.

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.

Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH.

Nat Cell Biol. 2007 Mar;9(3):316-23. Epub 2007 Feb 4.

PMID:
17277771
19.
20.

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.

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