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Items: 1 to 20 of 108

1.

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

Cai Z, Chehab NH, Pavletich NP.

Mol Cell. 2009 Sep 24;35(6):818-29. doi: 10.1016/j.molcel.2009.09.007.

2.

Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.

Tan CS, Bodenmiller B, Pasculescu A, Jovanovic M, Hengartner MO, Jørgensen C, Bader GD, Aebersold R, Pawson T, Linding R.

Sci Signal. 2009 Jul 28;2(81):ra39. doi: 10.1126/scisignal.2000316.

3.

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

Reinhardt HC, Yaffe MB.

Curr Opin Cell Biol. 2009 Apr;21(2):245-55. doi: 10.1016/j.ceb.2009.01.018. Epub 2009 Feb 21. Review.

4.

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.

Sur S, Pagliarini R, Bunz F, Rago C, Diaz LA Jr, Kinzler KW, Vogelstein B, Papadopoulos N.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3964-9. doi: 10.1073/pnas.0813333106. Epub 2009 Feb 18.

5.

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.

Cell. 2009 Feb 6;136(3):435-46. doi: 10.1016/j.cell.2008.12.041.

6.

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.

Cell. 2009 Feb 6;136(3):420-34. doi: 10.1016/j.cell.2008.12.042.

7.

Cell cycle control by the CDC25 phosphatases.

Aressy B, Ducommun B.

Anticancer Agents Med Chem. 2008 Dec;8(8):818-24. Review.

PMID:
19075563
8.

NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.

Wilson KA, Stern DF.

Cell Cycle. 2008 Nov 15;7(22):3584-94. Epub 2008 Nov 29.

9.

Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions.

Li J, Taylor IA, Lloyd J, Clapperton JA, Howell S, MacMillan D, Smerdon SJ.

J Biol Chem. 2008 Dec 19;283(51):36019-30. doi: 10.1074/jbc.M804075200. Epub 2008 Oct 23.

10.

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.

Dimitrova N, Chen YC, Spector DL, de Lange T.

Nature. 2008 Nov 27;456(7221):524-8. doi: 10.1038/nature07433. Epub 2008 Oct 19.

11.

53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.

Nature. 2008 Nov 27;456(7221):529-33. doi: 10.1038/nature07476. Epub 2008 Oct 19.

12.

Linear motif atlas for phosphorylation-dependent signaling.

Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R.

Sci Signal. 2008 Sep 2;1(35):ra2. doi: 10.1126/scisignal.1159433.

13.

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.

Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.

Nature. 2008 Sep 4;455(7209):119-23. doi: 10.1038/nature07185. Epub 2008 Jul 9.

PMID:
18615013
14.

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.

Seki A, Coppinger JA, Jang CY, Yates JR, Fang G.

Science. 2008 Jun 20;320(5883):1655-8. doi: 10.1126/science.1157425.

15.

Aurora kinases as anticancer drug targets.

Gautschi O, Heighway J, Mack PC, Purnell PR, Lara PN Jr, Gandara DR.

Clin Cancer Res. 2008 Mar 15;14(6):1639-48. doi: 10.1158/1078-0432.CCR-07-2179. Review.

16.

The DNA damage response: ten years after.

Harper JW, Elledge SJ.

Mol Cell. 2007 Dec 14;28(5):739-45. Review.

17.

Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.

Skoufias DA, Indorato RL, Lacroix F, Panopoulos A, Margolis RL.

J Cell Biol. 2007 Nov 19;179(4):671-85.

18.

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J.

Cell. 2007 Nov 30;131(5):901-14. Epub 2007 Nov 20.

19.

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.

20.

Ensembl 2008.

Flicek P, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G, Cunningham F, Cutts T, Down T, Dyer SC, Eyre T, Fitzgerald S, Fernandez-Banet J, Gräf S, Haider S, Hammond M, Holland R, Howe KL, Howe K, Johnson N, Jenkinson A, Kähäri A, Keefe D, Kokocinski F, Kulesha E, Lawson D, Longden I, Megy K, Meidl P, Overduin B, Parker A, Pritchard B, Prlic A, Rice S, Rios D, Schuster M, Sealy I, Slater G, Smedley D, Spudich G, Trevanion S, Vilella AJ, Vogel J, White S, Wood M, Birney E, Cox T, Curwen V, Durbin R, Fernandez-Suarez XM, Herrero J, Hubbard TJ, Kasprzyk A, Proctor G, Smith J, Ureta-Vidal A, Searle S.

Nucleic Acids Res. 2008 Jan;36(Database issue):D707-14. Epub 2007 Nov 13.

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