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Items: 1 to 20 of 65

1.

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR.

Cell. 2009 Aug 7;138(3):562-75. doi: 10.1016/j.cell.2009.07.017.

2.

Endoplasmic reticulum stress in beta-cells and development of diabetes.

Fonseca SG, Burcin M, Gromada J, Urano F.

Curr Opin Pharmacol. 2009 Dec;9(6):763-70. doi: 10.1016/j.coph.2009.07.003. Epub 2009 Aug 6. Review.

3.

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells.

Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS.

J Cell Biol. 2009 Aug 10;186(3):323-31. doi: 10.1083/jcb.200903014. Epub 2009 Aug 3.

4.

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.

Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ.

J Clin Invest. 2008 Oct;118(10):3378-89. doi: 10.1172/JCI34587.

5.

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17.

6.

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.

Scheuner D, Kaufman RJ.

Endocr Rev. 2008 May;29(3):317-33. doi: 10.1210/er.2007-0039. Epub 2008 Apr 24. Review. Erratum in: Endocr Rev. 2008 Aug;29(5):631.

7.

The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.

Lipson KL, Ghosh R, Urano F.

PLoS One. 2008 Feb 20;3(2):e1648. doi: 10.1371/journal.pone.0001648.

8.

The role for endoplasmic reticulum stress in diabetes mellitus.

Eizirik DL, Cardozo AK, Cnop M.

Endocr Rev. 2008 Feb;29(1):42-61. Epub 2007 Nov 29. Review.

PMID:
18048764
9.

That which does not kill me makes me stronger: adapting to chronic ER stress.

Rutkowski DT, Kaufman RJ.

Trends Biochem Sci. 2007 Oct;32(10):469-76.

PMID:
17920280
10.

Insulin gene mutations as a cause of permanent neonatal diabetes.

Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12.

11.

Signal integration in the endoplasmic reticulum unfolded protein response.

Ron D, Walter P.

Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29. Review.

PMID:
17565364
12.

Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.

Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R.

Diabetes. 2007 May;56(5):1268-76. Epub 2007 Feb 15.

13.

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.

14.
15.

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.

Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ.

PLoS Biol. 2006 Nov;4(11):e374.

16.

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA, Urano F.

Cell Metab. 2006 Sep;4(3):245-54.

17.

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

Hollien J, Weissman JS.

Science. 2006 Jul 7;313(5783):104-7.

18.

Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.

Pirot P, Eizirik DL, Cardozo AK.

Diabetologia. 2006 Jun;49(6):1229-36. Epub 2006 Apr 8.

PMID:
16604358
19.

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A.

Endocrinology. 2006 Jul;147(7):3398-407. Epub 2006 Apr 6.

PMID:
16601139
20.

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.

Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, Welling C, Murray J, Schmidt RE, Herrera PL, Permutt MA.

Diabetologia. 2005 Nov;48(11):2313-21. Epub 2005 Oct 8.

PMID:
16215705

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