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Items: 1 to 20 of 24

1.

Characterization of BRCA1 ring finger variants of uncertain significance.

Sweet K, Senter L, Pilarski R, Wei L, Toland AE.

Breast Cancer Res Treat. 2010 Feb;119(3):737-43. doi: 10.1007/s10549-009-0438-6. Epub 2009 Jun 20.

2.

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20876-81. doi: 10.1073/pnas.0811203106. Epub 2008 Dec 16.

3.

Assessment of functional effects of unclassified genetic variants.

Couch FJ, Rasmussen LJ, Hofstra R, Monteiro AN, Greenblatt MS, de Wind N; IARC Unclassified Genetic Variants Working Group.

Hum Mutat. 2008 Nov;29(11):1314-26. doi: 10.1002/humu.20899.

4.

Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance.

Spearman AD, Sweet K, Zhou XP, McLennan J, Couch FJ, Toland AE.

J Clin Oncol. 2008 Nov 20;26(33):5393-400. doi: 10.1200/JCO.2008.17.8228. Epub 2008 Sep 29. Erratum in: J Clin Oncol. 2009 May 10;27(14):2415.

5.

A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes.

Easton DF, Deffenbaugh AM, Pruss D, Frye C, Wenstrup RJ, Allen-Brady K, Tavtigian SV, Monteiro AN, Iversen ES, Couch FJ, Goldgar DE.

Am J Hum Genet. 2007 Nov;81(5):873-83. Epub 2007 Sep 6.

6.

Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair.

Laufer M, Nandula SV, Modi AP, Wang S, Jasin M, Murty VV, Ludwig T, Baer R.

J Biol Chem. 2007 Nov 23;282(47):34325-33. Epub 2007 Sep 11.

7.

Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis.

Carvalho MA, Marsillac SM, Karchin R, Manoukian S, Grist S, Swaby RF, Urmenyi TP, Rondinelli E, Silva R, Gayol L, Baumbach L, Sutphen R, Pickard-Brzosowicz JL, Nathanson KL, Sali A, Goldgar D, Couch FJ, Radice P, Monteiro AN.

Cancer Res. 2007 Feb 15;67(4):1494-501.

8.

Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division.

Nakanishi A, Han X, Saito H, Taguchi K, Ohta Y, Imajoh-Ohmi S, Miki Y.

Biochem Biophys Res Commun. 2007 Mar 30;355(1):34-40. Epub 2007 Jan 26.

PMID:
17286961
9.

Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function.

Sankaran S, Starita LM, Simons AM, Parvin JD.

Cancer Res. 2006 Apr 15;66(8):4100-7.

10.

Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.

Morris JR, Pangon L, Boutell C, Katagiri T, Keep NH, Solomon E.

Hum Mol Genet. 2006 Feb 15;15(4):599-606. Epub 2006 Jan 10.

PMID:
16403807
11.

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

Starita LM, Horwitz AA, Keogh MC, Ishioka C, Parvin JD, Chiba N.

J Biol Chem. 2005 Jul 1;280(26):24498-505. Epub 2005 May 10.

12.

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

Starita LM, Machida Y, Sankaran S, Elias JE, Griffin K, Schlegel BP, Gygi SP, Parvin JD.

Mol Cell Biol. 2004 Oct;24(19):8457-66.

13.

The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme.

Chiba N, Parvin JD.

Cancer Res. 2002 Aug 1;62(15):4222-8.

14.

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.

Pierce AJ, Hu P, Han M, Ellis N, Jasin M.

Genes Dev. 2001 Dec 15;15(24):3237-42.

15.

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE.

Nat Struct Biol. 2001 Oct;8(10):833-7.

PMID:
11573085
16.

The R71G BRCA1 is a founder Spanish mutation and leads to aberrant splicing of the transcript.

Vega A, Campos B, Bressac-De-Paillerets B, Bond PM, Janin N, Douglas FS, Domènech M, Baena M, Pericay C, Alonso C, Carracedo A, Baiget M, Diez O.

Hum Mutat. 2001 Jun;17(6):520-1.

PMID:
11385711
17.
18.

BRCA2 is required for homology-directed repair of chromosomal breaks.

Moynahan ME, Pierce AJ, Jasin M.

Mol Cell. 2001 Feb;7(2):263-72.

20.

Brca1 controls homology-directed DNA repair.

Moynahan ME, Chiu JW, Koller BH, Jasin M.

Mol Cell. 1999 Oct;4(4):511-8.

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