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Items: 1 to 20 of 29

1.

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.

Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R.

Science. 2009 Sep 4;325(5945):1261-5. doi: 10.1126/science.1173569.

2.

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA.

Cancer Cell. 2009 Jul 7;16(1):21-32. doi: 10.1016/j.ccr.2009.04.012.

3.

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas.

Shoji K, Oda K, Nakagawa S, Hosokawa S, Nagae G, Uehara Y, Sone K, Miyamoto Y, Hiraike H, Hiraike-Wada O, Nei T, Kawana K, Kuramoto H, Aburatani H, Yano T, Taketani Y.

Br J Cancer. 2009 Jul 7;101(1):145-8. doi: 10.1038/sj.bjc.6605109. Epub 2009 Jun 2.

4.

Knockin of mutant PIK3CA activates multiple oncogenic pathways.

Gustin JP, Karakas B, Weiss MB, Abukhdeir AM, Lauring J, Garay JP, Cosgrove D, Tamaki A, Konishi H, Konishi Y, Mohseni M, Wang G, Rosen DM, Denmeade SR, Higgins MJ, Vitolo MI, Bachman KE, Park BH.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2835-40. doi: 10.1073/pnas.0813351106. Epub 2009 Feb 5.

5.

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses.

Di Nicolantonio F, Arena S, Gallicchio M, Zecchin D, Martini M, Flonta SE, Stella GM, Lamba S, Cancelliere C, Russo M, Geuna M, Appendino G, Fantozzi R, Medico E, Bardelli A.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20864-9. doi: 10.1073/pnas.0808757105. Epub 2008 Dec 23.

6.

A novel AKT3 mutation in melanoma tumours and cell lines.

Davies MA, Stemke-Hale K, Tellez C, Calderone TL, Deng W, Prieto VG, Lazar AJ, Gershenwald JE, Mills GB.

Br J Cancer. 2008 Oct 21;99(8):1265-8. doi: 10.1038/sj.bjc.6604637. Epub 2008 Sep 23.

7.

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.

Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT.

Cancer Res. 2008 Aug 1;68(15):6084-91. doi: 10.1158/0008-5472.CAN-07-6854.

8.

AKT1(E17K) in human solid tumours.

Bleeker FE, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M, Scarpa A, Leenstra S, Frattini M, Barbareschi M, Grammastro MD, Sciarrotta MG, Zanon C, Marchetti A, Bardelli A.

Oncogene. 2008 Sep 18;27(42):5648-50. doi: 10.1038/onc.2008.170. Epub 2008 May 26.

PMID:
18504432
9.

Biochemical and biological characterization of tumor-associated mutations of p110alpha.

Denley A, Gymnopoulos M, Hart JR, Jiang H, Zhao L, Vogt PK.

Methods Enzymol. 2008;438:291-305. doi: 10.1016/S0076-6879(07)38020-8.

PMID:
18413256
10.

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias.

Kim MS, Jeong EG, Yoo NJ, Lee SH.

Br J Cancer. 2008 May 6;98(9):1533-5. doi: 10.1038/sj.bjc.6604212. Epub 2008 Apr 8.

11.

A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting.

Konishi H, Lauring J, Garay JP, Karakas B, Abukhdeir AM, Gustin JP, Konishi Y, Park BH.

Nat Protoc. 2007;2(11):2865-74.

PMID:
18007621
12.

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

Lauring J, Abukhdeir AM, Konishi H, Garay JP, Gustin JP, Wang Q, Arceci RJ, Matsui W, Park BH.

Blood. 2008 Jan 15;111(2):856-64. Epub 2007 Oct 17.

13.

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers.

Arena S, Isella C, Martini M, de Marco A, Medico E, Bardelli A.

Cancer Res. 2007 Sep 15;67(18):8468-76.

14.

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.

Konishi H, Karakas B, Abukhdeir AM, Lauring J, Gustin JP, Garay JP, Konishi Y, Gallmeier E, Bachman KE, Park BH.

Cancer Res. 2007 Sep 15;67(18):8460-7.

15.

PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma.

Abubaker J, Bavi PP, Al-Harbi S, Siraj AK, Al-Dayel F, Uddin S, Al-Kuraya K.

Leukemia. 2007 Nov;21(11):2368-70. Epub 2007 Jul 26. No abstract available.

PMID:
17657213
16.

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.

Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE.

Nature. 2007 Jul 26;448(7152):439-44. Epub 2007 Jul 4.

PMID:
17611497
17.

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer.

Pérez-Tenorio G, Alkhori L, Olsson B, Waltersson MA, Nordenskjöld B, Rutqvist LE, Skoog L, Stål O.

Clin Cancer Res. 2007 Jun 15;13(12):3577-84.

18.

PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia.

Hayes MP, Wang H, Espinal-Witter R, Douglas W, Solomon GJ, Baker SJ, Ellenson LH.

Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5932-5.

19.

The consensus coding sequences of human breast and colorectal cancers.

Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.

Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.

20.

Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells.

Abukhdeir AM, Blair BG, Brenner K, Karakas B, Konishi H, Lim J, Sahasranaman V, Huang Y, Keen J, Davidson N, Vitolo MI, Bachman KE, Park BH.

Breast Cancer Res Treat. 2006 Sep;99(1):23-33. Epub 2006 Mar 16.

PMID:
16541319

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