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Items: 1 to 20 of 43


Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats.

Zhao CX, Xu X, Cui Y, Wang P, Wei X, Yang S, Edin ML, Zeldin DC, Wang DW.

J Pharmacol Exp Ther. 2009 Feb;328(2):610-20. doi: 10.1124/jpet.108.143396. Epub 2008 Nov 13.


Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.

Watanabe T, Kubota N, Ohsugi M, Kubota T, Takamoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Tokuyama K, Moroi M, Sugi K, Yamauchi T, Noda T, Nagai R, Terauchi Y, Tobe K, Ueki K, Kadowaki T.

J Biol Chem. 2009 Jan 16;284(3):1803-12. doi: 10.1074/jbc.M807120200. Epub 2008 Nov 13.


Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice.

Hercule HC, Schunck WH, Gross V, Seringer J, Leung FP, Weldon SM, da Costa Goncalves ACh, Huang Y, Luft FC, Gollasch M.

Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):54-60. doi: 10.1161/ATVBAHA.108.171298. Epub 2008 Oct 16.


Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance.

Toutouzas K, Riga M, Stefanadi E, Stefanadis C.

Horm Metab Res. 2008 Sep;40(9):655-9. doi: 10.1055/s-0028-1083814. Epub 2008 Sep 15. Review.


Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation.

Tan HW, Xing SS, Bi XP, Li L, Gong HP, Zhong M, Zhang Y, Zhang W.

Acta Pharmacol Sin. 2008 Sep;29(9):1051-9. doi: 10.1111/j.1745-7254.2008.00843.x.


Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease.

Hutchinson DS, Summers RJ, Bengtsson T.

Pharmacol Ther. 2008 Sep;119(3):291-310. doi: 10.1016/j.pharmthera.2008.05.008. Epub 2008 Jun 17. Review.


Fructose induces the inflammatory molecule ICAM-1 in endothelial cells.

Glushakova O, Kosugi T, Roncal C, Mu W, Heinig M, Cirillo P, Sánchez-Lozada LG, Johnson RJ, Nakagawa T.

J Am Soc Nephrol. 2008 Sep;19(9):1712-20. doi: 10.1681/ASN.2007121304. Epub 2008 May 28.


A high-fructose diet impairs Akt and PKCzeta phosphorylation and GLUT4 translocation in rat skeletal muscle.

Li P, Koike T, Qin B, Kubota M, Kawata Y, Jia YJ, Oshida Y.

Horm Metab Res. 2008 Aug;40(8):528-32. doi: 10.1055/s-2008-1073162. Epub 2008 May 21.


Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5.

Singh AK, Amlal H, Haas PJ, Dringenberg U, Fussell S, Barone SL, Engelhardt R, Zuo J, Seidler U, Soleimani M.

Kidney Int. 2008 Aug;74(4):438-47. doi: 10.1038/ki.2008.184. Epub 2008 May 21.


Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats.

Tu L, Xu X, Wan H, Zhou C, Deng J, Xu G, Xiao X, Chen Y, Edin ML, Voltz JW, Zeldin DC, Wang DW.

Hum Gene Ther. 2008 Apr;19(4):318-30. doi: 10.1089/hum.2007.138.


Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance.

Liang H, Yin B, Zhang H, Zhang S, Zeng Q, Wang J, Jiang X, Yuan L, Wang CY, Li Z.

Endocrinology. 2008 Jun;149(6):2943-51. doi: 10.1210/en.2007-0978. Epub 2008 Mar 13.


Thiazide diuretics exacerbate fructose-induced metabolic syndrome.

Reungjui S, Roncal CA, Mu W, Srinivas TR, Sirivongs D, Johnson RJ, Nakagawa T.

J Am Soc Nephrol. 2007 Oct;18(10):2724-31. Epub 2007 Sep 12.


Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway.

Li G, Barrett EJ, Barrett MO, Cao W, Liu Z.

Endocrinology. 2007 Jul;148(7):3356-63. Epub 2007 Apr 19.


Nitric oxide-dependent endothelial function and cardiovascular disease.

Desjardins F, Balligand JL.

Acta Clin Belg. 2006 Nov-Dec;61(6):326-34. Review.


Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways.

Yang S, Lin L, Chen JX, Lee CR, Seubert JM, Wang Y, Wang H, Chao ZR, Tao DD, Gong JP, Lu ZY, Wang DW, Zeldin DC.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H142-51. Epub 2007 Feb 23.


Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension.

Wu SN, Zhang Y, Gardner CO, Chen Q, Li Y, Wang GL, Gao PJ, Zhu DL.

Ann Hum Genet. 2007 Jul;71(Pt 4):519-25. Epub 2007 Feb 5.


Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, Dickinson R, Adler A, Gagne G, Iyengar R, Zhao G, Marsh K, Kym P, Jung P, Camp HS, Frevert E.

Cell Metab. 2006 Jun;3(6):403-16.


Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.

Jiang JG, Chen CL, Card JW, Yang S, Chen JX, Fu XN, Ning YG, Xiao X, Zeldin DC, Wang DW.

Cancer Res. 2005 Jun 1;65(11):4707-15.


Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways.

Wang Y, Wei X, Xiao X, Hui R, Card JW, Carey MA, Wang DW, Zeldin DC.

J Pharmacol Exp Ther. 2005 Aug;314(2):522-32. Epub 2005 Apr 19.


NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.

Satoh M, Fujimoto S, Haruna Y, Arakawa S, Horike H, Komai N, Sasaki T, Tsujioka K, Makino H, Kashihara N.

Am J Physiol Renal Physiol. 2005 Jun;288(6):F1144-52. Epub 2005 Feb 1.

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