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Items: 1 to 20 of 44


Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status.

Villanueva EC, Münzberg H, Cota D, Leshan RL, Kopp K, Ishida-Takahashi R, Jones JC, Fingar DC, Seeley RJ, Myers MG Jr.

Endocrinology. 2009 Oct;150(10):4541-51. doi: 10.1210/en.2009-0642. Epub 2009 Jul 23.


Leptin targets in the mouse brain.

Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK.

J Comp Neurol. 2009 Jun 10;514(5):518-32. doi: 10.1002/cne.22025.


Endoplasmic reticulum stress plays a central role in development of leptin resistance.

Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr, Ozcan U.

Cell Metab. 2009 Jan 7;9(1):35-51. doi: 10.1016/j.cmet.2008.12.004.


Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.

Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D.

Cell. 2008 Oct 3;135(1):61-73. doi: 10.1016/j.cell.2008.07.043.


Endoplasmic reticulum stress induces leptin resistance.

Hosoi T, Sasaki M, Miyahara T, Hashimoto C, Matsuo S, Yoshii M, Ozawa K.

Mol Pharmacol. 2008 Dec;74(6):1610-9. doi: 10.1124/mol.108.050070. Epub 2008 Aug 28.


Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.

Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS.

Endocrinology. 2008 Nov;149(11):5654-61. doi: 10.1210/en.2008-0805. Epub 2008 Jul 31.


The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.

Cota D, Matter EK, Woods SC, Seeley RJ.

J Neurosci. 2008 Jul 9;28(28):7202-8. doi: 10.1523/JNEUROSCI.1389-08.2008.


Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964.


Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons.

Piper ML, Unger EK, Myers MG Jr, Xu AW.

Mol Endocrinol. 2008 Mar;22(3):751-9. Epub 2007 Dec 20.


Mechanisms of leptin action and leptin resistance.

Myers MG, Cowley MA, Münzberg H.

Annu Rev Physiol. 2008;70:537-56. Review.


Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance.

Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E 3rd, Zhang Y.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16158-63. Epub 2007 Oct 2. Erratum in: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19655.


Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.

Davenport JR, Watts AJ, Roper VC, Croyle MJ, van Groen T, Wyss JM, Nagy TR, Kesterson RA, Yoder BK.

Curr Biol. 2007 Sep 18;17(18):1586-94. Epub 2007 Sep 6.


Differential accessibility of circulating leptin to individual hypothalamic sites.

Faouzi M, Leshan R, Björnholm M, Hennessey T, Jones J, Münzberg H.

Endocrinology. 2007 Nov;148(11):5414-23. Epub 2007 Aug 9.


AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.


Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities.

Guo K, McMinn JE, Ludwig T, Yu YH, Yang G, Chen L, Loh D, Li C, Chua S Jr, Zhang Y.

Endocrinology. 2007 Aug;148(8):3987-97. Epub 2007 May 10.


Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons.

Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK, Glavas MM, Grayson BE, Perello M, Nillni EA, Grove KL, Cowley MA.

Cell Metab. 2007 Mar;5(3):181-94.


A key role of leptin in the control of regulatory T cell proliferation.

De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G.

Immunity. 2007 Feb;26(2):241-55.


Leptin receptor signaling and action in the central nervous system.

Leshan RL, Björnholm M, Münzberg H, Myers MG Jr.

Obesity (Silver Spring). 2006 Aug;14 Suppl 5:208S-212S. Review.

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