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Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.

Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1263-73. doi: 10.1152/ajpheart.00152.2009. Epub 2009 Aug 21.


Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel.

Tandan S, Wang Y, Wang TT, Jiang N, Hall DD, Hell JW, Luo X, Rothermel BA, Hill JA.

Circ Res. 2009 Jul 2;105(1):51-60. doi: 10.1161/CIRCRESAHA.109.199828. Epub 2009 May 28.


Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathway.

Orie NN, Thomas AM, Perrino BA, Tinker A, Clapp LH.

Br J Pharmacol. 2009 Jun;157(4):554-64. doi: 10.1111/j.1476-5381.2009.00221.x. Epub 2009 May 7.


Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.

Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR.

Science. 2009 Jan 30;323(5914):651-4. doi: 10.1126/science.1166562.


Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.

Turgeon B, Meloche S.

Physiol Rev. 2009 Jan;89(1):1-26. doi: 10.1152/physrev.00040.2007. Review.


Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15803-8. doi: 10.1073/pnas.0808249105. Epub 2008 Oct 6.


Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure.

Joubert F, Wilding JR, Fortin D, Domergue-Dupont V, Novotova M, Ventura-Clapier R, Veksler V.

J Physiol. 2008 Nov 1;586(21):5181-92. doi: 10.1113/jphysiol.2008.157677. Epub 2008 Sep 11.


DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility.

Maillet M, Purcell NH, Sargent MA, York AJ, Bueno OF, Molkentin JD.

J Biol Chem. 2008 Nov 7;283(45):31246-55. doi: 10.1074/jbc.M806085200. Epub 2008 Aug 27.


The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors.

Medyouf H, Ghysdael J.

Cell Cycle. 2008 Feb 1;7(3):297-303. Epub 2007 Nov 23. Review.


Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.

Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Crombleholme TM, Molkentin JD.

J Clin Invest. 2007 Nov;117(11):3198-210. Erratum in: J Clin Invest. 2008 Jan;118(1):387. Cromblehol, Timothy M [corrected to Crombleholme, Timothy M].


Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.

Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H, Jaleel N, Chua BH, Hewett TE, Robbins J, Houser SR, Molkentin JD.

J Clin Invest. 2007 Sep;117(9):2431-44.


NFAT signaling and the invention of vertebrates.

Wu H, Peisley A, Graef IA, Crabtree GR.

Trends Cell Biol. 2007 Jun;17(6):251-60. Epub 2007 May 10.


Regulation of the cardiac Na+/Ca2+ exchanger by calcineurin and protein kinase C.

Shigekawa M, Katanosaka Y, Wakabayashi S.

Ann N Y Acad Sci. 2007 Mar;1099:53-63.


Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.

Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD.

Nat Cell Biol. 2007 May;9(5):550-5. Epub 2007 Apr 8.


Calcineurin/Nfat signaling is required for perinatal lung maturation and function.

Davé V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert SE, Neilson JR, Crabtree GR, Whitsett JA.

J Clin Invest. 2006 Oct;116(10):2597-609. Epub 2006 Sep 21.


Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.

Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK.

Nature. 2006 Sep 21;443(7109):345-9.


Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.

Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD.

Circ Res. 2006 Mar 31;98(6):837-45. Epub 2006 Mar 2.


PKC-independent signal transduction pathways increase SERCA2 expression in adult rat cardiomyocytes.

Anwar A, Taimor G, Korkusuz H, Schreckenberg R, Berndt T, Abdallah Y, Piper HM, Schlüter KD.

J Mol Cell Cardiol. 2005 Dec;39(6):911-9. Epub 2005 Oct 17. Erratum in: J Mol Cell Cardiol. 2012 Mar;52(3):783. Korkususz, Hüdayi [corrected to Korkusuz, Hüdayi].


Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.

Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP.

Dev Cell. 2005 May;8(5):665-76.


A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.

Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR.

Cell. 2004 Sep 3;118(5):649-63.

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