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Items: 1 to 20 of 115

1.

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC.

J Biol Chem. 2010 Jan 1;285(1):80-94. doi: 10.1074/jbc.M109.029637. Epub 2009 Oct 28.

2.

Mapping the phosphorylation sites of Ulk1.

Dorsey FC, Rose KL, Coenen S, Prater SM, Cavett V, Cleveland JL, Caldwell-Busby J.

J Proteome Res. 2009 Nov;8(11):5253-63. doi: 10.1021/pr900583m.

PMID:
19807128
3.

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy.

Stephan JS, Yeh YY, Ramachandran V, Deminoff SJ, Herman PK.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17049-54. doi: 10.1073/pnas.0903316106. Epub 2009 Sep 21.

4.

Discovery of Atg5/Atg7-independent alternative macroautophagy.

Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S.

Nature. 2009 Oct 1;461(7264):654-8. doi: 10.1038/nature08455. Erratum in: Nature. 2016 May 5;533(7601):130.

PMID:
19794493
5.

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG, Nabi IR, Roberge M.

PLoS One. 2009 Sep 22;4(9):e7124. doi: 10.1371/journal.pone.0007124.

6.

The Vam6 GEF controls TORC1 by activating the EGO complex.

Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C.

Mol Cell. 2009 Sep 11;35(5):563-73. doi: 10.1016/j.molcel.2009.06.033.

7.

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.

Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, Aebersold R, Loewith R.

Genes Dev. 2009 Aug 15;23(16):1929-43. doi: 10.1101/gad.532109.

8.

Regulation mechanisms and signaling pathways of autophagy.

He C, Klionsky DJ.

Annu Rev Genet. 2009;43:67-93. doi: 10.1146/annurev-genet-102808-114910. Review.

9.

Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth.

Schleich S, Teleman AA.

PLoS One. 2009 Jul 17;4(7):e6305. doi: 10.1371/journal.pone.0006305.

10.

Atg101, a novel mammalian autophagy protein interacting with Atg13.

Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N.

Autophagy. 2009 Oct;5(7):973-9. Epub 2009 Oct 18.

PMID:
19597335
11.

Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion.

Fielhaber JA, Han YS, Tan J, Xing S, Biggs CM, Joung KB, Kristof AS.

J Biol Chem. 2009 Sep 4;284(36):24341-53. doi: 10.1074/jbc.M109.033530. Epub 2009 Jun 24.

12.

Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation.

Kumar SH, Rangarajan A.

J Virol. 2009 Sep;83(17):8565-74. doi: 10.1128/JVI.00603-09. Epub 2009 Jun 10.

13.

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM.

Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14.

14.

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.

Salazar M, Carracedo A, Salanueva IJ, Hernández-Tiedra S, Lorente M, Egia A, Vázquez P, Blázquez C, Torres S, García S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, González-Feria L, Iovanna JL, Guzmán M, Boya P, Velasco G.

J Clin Invest. 2009 May;119(5):1359-72.

15.

VMA21 deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification.

Ramachandran N, Munteanu I, Wang P, Aubourg P, Rilstone JJ, Israelian N, Naranian T, Paroutis P, Guo R, Ren ZP, Nishino I, Chabrol B, Pellissier JF, Minetti C, Udd B, Fardeau M, Tailor CS, Mahuran DJ, Kissel JT, Kalimo H, Levy N, Manolson MF, Ackerley CA, Minassian BA.

Cell. 2009 Apr 17;137(2):235-46. doi: 10.1016/j.cell.2009.01.054. Retraction in: Cell. 2010 Sep 17;142(6):984.

16.

epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans.

Tian E, Wang F, Han J, Zhang H.

Autophagy. 2009 Jul;5(5):608-15. Epub 2009 Jul 2.

PMID:
19377305
17.

Atg17 recruits Atg9 to organize the pre-autophagosomal structure.

Sekito T, Kawamata T, Ichikawa R, Suzuki K, Ohsumi Y.

Genes Cells. 2009 May;14(5):525-38. doi: 10.1111/j.1365-2443.2009.01299.x. Epub 2009 Apr 13.

18.

Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

Wang L, Lawrence JC Jr, Sturgill TW, Harris TE.

J Biol Chem. 2009 May 29;284(22):14693-7. doi: 10.1074/jbc.C109.002907. Epub 2009 Apr 3.

19.

Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.

Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, Shore D.

Mol Cell. 2009 Mar 27;33(6):704-16. doi: 10.1016/j.molcel.2009.01.034.

20.

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.

Vicencio JM, Ortiz C, Criollo A, Jones AW, Kepp O, Galluzzi L, Joza N, Vitale I, Morselli E, Tailler M, Castedo M, Maiuri MC, Molgó J, Szabadkai G, Lavandero S, Kroemer G.

Cell Death Differ. 2009 Jul;16(7):1006-17. doi: 10.1038/cdd.2009.34. Epub 2009 Mar 27.

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