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Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease.

Dziewczapolski G, Glogowski CM, Masliah E, Heinemann SF.

J Neurosci. 2009 Jul 8;29(27):8805-15. doi: 10.1523/JNEUROSCI.6159-08.2009.


Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.

Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI.

Science. 2009 Feb 20;323(5917):1063-6. doi: 10.1126/science.1165946. Erratum in: Science. 2013 Nov 22;342(6161):931.


Association of FOXO3A variation with human longevity confirmed in German centenarians.

Flachsbart F, Caliebe A, Kleindorp R, Blanché H, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2700-5. doi: 10.1073/pnas.0809594106. Epub 2009 Feb 5.


SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.

Cell. 2008 Nov 28;135(5):907-18. doi: 10.1016/j.cell.2008.10.025.


The anti-aging, metabolism potential of SIRT1.

Ghosh HS.

Curr Opin Investig Drugs. 2008 Oct;9(10):1095-102. Review.


The insulin paradox: aging, proteotoxicity and neurodegeneration.

Cohen E, Dillin A.

Nat Rev Neurosci. 2008 Oct;9(10):759-67. doi: 10.1038/nrn2474. Epub 2008 Sep 4. Review.


FOXO3A genotype is strongly associated with human longevity.

Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13987-92. doi: 10.1073/pnas.0801030105. Epub 2008 Sep 2.


Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease.

Wirths O, Breyhan H, Marcello A, Cotel MC, Brück W, Bayer TA.

Neurobiol Aging. 2010 May;31(5):747-57. doi: 10.1016/j.neurobiolaging.2008.06.011. Epub 2008 Jul 26.


Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ.

Nat Med. 2008 Aug;14(8):837-42. doi: 10.1038/nm1782. Epub 2008 Jun 22.


IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP.

Nadjar A, Berton O, Guo S, Leneuve P, Dovero S, Diguet E, Tison F, Zhao B, Holzenberger M, Bezard E.

Neurobiol Aging. 2009 Dec;30(12):2021-30. doi: 10.1016/j.neurobiolaging.2008.02.009. Epub 2008 Apr 3.


Forkhead transcription factors and ageing.

Partridge L, Brüning JC.

Oncogene. 2008 Apr 7;27(16):2351-63. doi: 10.1038/onc.2008.28. Review.


Functionally significant insulin-like growth factor I receptor mutations in centenarians.

Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3438-42. doi: 10.1073/pnas.0705467105. Epub 2008 Mar 3.


Insulin-like signaling, nutrient homeostasis, and life span.

Taguchi A, White MF.

Annu Rev Physiol. 2008;70:191-212. Review.


Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease.

Fukui H, Diaz F, Garcia S, Moraes CT.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14163-8. Epub 2007 Aug 21.


Brain IRS2 signaling coordinates life span and nutrient homeostasis.

Taguchi A, Wartschow LM, White MF.

Science. 2007 Jul 20;317(5836):369-72.


Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L.

J Biol Chem. 2007 Aug 17;282(33):23818-28. Epub 2007 Jun 4.


Impairment of spatial memory consolidation in APP(751SL) mice results in cue-guided response.

Blanchard J, Martel G, Guillou JL, Noguès X, Micheau J.

Neurobiol Aging. 2008 Jul;29(7):1011-21. Epub 2007 Mar 12.


Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Haass C, Selkoe DJ.

Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12. Review.


Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.

Reiserer RS, Harrison FE, Syverud DC, McDonald MP.

Genes Brain Behav. 2007 Feb;6(1):54-65.


Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

Behrends C, Langer CA, Boteva R, Böttcher UM, Stemp MJ, Schaffar G, Rao BV, Giese A, Kretzschmar H, Siegers K, Hartl FU.

Mol Cell. 2006 Sep 15;23(6):887-97.

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