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Items: 1 to 20 of 113

1.

Dysregulation of mTOR signaling in fragile X syndrome.

Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E, Zukin RS.

J Neurosci. 2010 Jan 13;30(2):694-702. doi: 10.1523/JNEUROSCI.3696-09.2010.

2.

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.

Dibble CC, Asara JM, Manning BD.

Mol Cell Biol. 2009 Nov;29(21):5657-70. doi: 10.1128/MCB.00735-09. Epub 2009 Aug 31.

3.

Review: autophagy in neurodegeneration: firefighter and/or incendiarist?

Rami A.

Neuropathol Appl Neurobiol. 2009 Oct;35(5):449-61. doi: 10.1111/j.1365-2990.2009.01034.x. Epub 2009 Jun 25. Review.

PMID:
19555462
4.

BDNF activates mTOR to regulate GluR1 expression required for memory formation.

Slipczuk L, Bekinschtein P, Katche C, Cammarota M, Izquierdo I, Medina JH.

PLoS One. 2009 Jun 23;4(6):e6007. doi: 10.1371/journal.pone.0006007.

5.

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).

García-Martínez JM, Moran J, Clarke RG, Gray A, Cosulich SC, Chresta CM, Alessi DR.

Biochem J. 2009 Jun 12;421(1):29-42. doi: 10.1042/BJ20090489.

6.

Regulation of the aging process by autophagy.

Salminen A, Kaarniranta K.

Trends Mol Med. 2009 May;15(5):217-24. doi: 10.1016/j.molmed.2009.03.004. Epub 2009 Apr 18. Review.

PMID:
19380253
7.

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition.

Dunlop EA, Dodd KM, Seymour LA, Tee AR.

Cell Signal. 2009 Jul;21(7):1073-84. doi: 10.1016/j.cellsig.2009.02.024. Epub 2009 Mar 9.

PMID:
19272448
8.

Translational control of long-lasting synaptic plasticity and memory.

Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N.

Neuron. 2009 Jan 15;61(1):10-26. doi: 10.1016/j.neuron.2008.10.055. Review.

9.

mTORC1 signalling and mRNA translation.

Proud CG.

Biochem Soc Trans. 2009 Feb;37(Pt 1):227-31. doi: 10.1042/BST0370227. Review.

PMID:
19143637
10.

A complex interplay between Akt, TSC2 and the two mTOR complexes.

Huang J, Manning BD.

Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22. doi: 10.1042/BST0370217. Review.

11.

Making synaptic plasticity and memory last: mechanisms of translational regulation.

Richter JD, Klann E.

Genes Dev. 2009 Jan 1;23(1):1-11. doi: 10.1101/gad.1735809. Review.

12.

Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior.

Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E.

Neuron. 2008 Dec 10;60(5):832-45. doi: 10.1016/j.neuron.2008.09.037.

13.

Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability.

Xue Q, Hopkins B, Perruzzi C, Udayakumar D, Sherris D, Benjamin LE.

Cancer Res. 2008 Nov 15;68(22):9551-7. doi: 10.1158/0008-5472.CAN-08-2058.

14.

The autistic neuron: troubled translation?

Kelleher RJ 3rd, Bear MF.

Cell. 2008 Oct 31;135(3):401-6. doi: 10.1016/j.cell.2008.10.017.

15.

Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases.

Krab LC, Goorden SM, Elgersma Y.

Trends Genet. 2008 Oct;24(10):498-510. doi: 10.1016/j.tig.2008.07.005. Epub 2008 Sep 4. Review.

PMID:
18774199
16.

The mTOR pathway and its role in human genetic diseases.

Rosner M, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschläger M.

Mutat Res. 2008 Sep-Oct;659(3):284-92. doi: 10.1016/j.mrrev.2008.06.001. Epub 2008 Jun 11. Review.

PMID:
18598780
17.

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.

Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ, Ramesh V, Silva AJ.

Nat Med. 2008 Aug;14(8):843-8. doi: 10.1038/nm1788. Epub 2008 Jun 22.

18.

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E.

EMBO J. 2008 Jul 23;27(14):1932-43. doi: 10.1038/emboj.2008.120. Epub 2008 Jun 19.

19.

Intracellular signaling by Akt: bound to be specific.

Franke TF.

Sci Signal. 2008 Jun 17;1(24):pe29. doi: 10.1126/scisignal.124pe29. Review.

PMID:
18560018
20.

What controls TOR?

Jacinto E.

IUBMB Life. 2008 Aug;60(8):483-96. doi: 10.1002/iub.56. Review.

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