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Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation.

Greenow KR, Clarke AR, Jones RH.

Oncogene. 2009 Mar 19;28(11):1443-53. doi: 10.1038/onc.2008.482. Epub 2009 Jan 26.


ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.

Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M.

PLoS Genet. 2009 Jan;5(1):e1000324. doi: 10.1371/journal.pgen.1000324. Epub 2009 Jan 2.


Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J.

PLoS Biol. 2008 Dec 2;6(12):2853-68. doi: 10.1371/journal.pbio.0060301.


The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.

Valentin-Vega YA, Okano H, Lozano G.

Cell Death Differ. 2008 Nov;15(11):1772-81. doi: 10.1038/cdd.2008.109. Epub 2008 Jul 18.


DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy.

Ashwell S, Zabludoff S.

Clin Cancer Res. 2008 Jul 1;14(13):4032-7. doi: 10.1158/1078-0432.CCR-07-5138. Review.


Identification of tumor-initiating cells in a p53-null mouse model of breast cancer.

Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM.

Cancer Res. 2008 Jun 15;68(12):4674-82. doi: 10.1158/0008-5472.CAN-07-6353.


How ATR turns on: TopBP1 goes on ATRIP with ATR.

Burrows AE, Elledge SJ.

Genes Dev. 2008 Jun 1;22(11):1416-21. doi: 10.1101/gad.1685108.


Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT.

Cell. 2008 May 30;133(5):864-77. doi: 10.1016/j.cell.2008.03.037.


Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, Zediak VP, Velez M, Bhandoola A, Brown EJ.

Cell Stem Cell. 2007 Jun 7;1(1):113-26. doi: 10.1016/j.stem.2007.03.002.


Rad9 has a functional role in human prostate carcinogenesis.

Zhu A, Zhang CX, Lieberman HB.

Cancer Res. 2008 Mar 1;68(5):1267-74. doi: 10.1158/0008-5472.CAN-07-2304.


Expression of DNA damage checkpoint protein Hus1 in epithelial ovarian tumors correlates with prognostic markers.

de la Torre J, Gil-Moreno A, García A, Rojo F, Xercavins J, Salido E, Freire R.

Int J Gynecol Pathol. 2008 Jan;27(1):24-32.


DNA damage signalling guards against activated oncogenes and tumour progression.

Bartek J, Bartkova J, Lukas J.

Oncogene. 2007 Dec 10;26(56):7773-9. Review.


Two faces of p53: aging and tumor suppression.

Rodier F, Campisi J, Bhaumik D.

Nucleic Acids Res. 2007;35(22):7475-84. Epub 2007 Oct 16. Review.


The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.

Verlinden L, Vanden Bempt I, Eelen G, Drijkoningen M, Verlinden I, Marchal K, De Wolf-Peeters C, Christiaens MR, Michiels L, Bouillon R, Verstuyf A.

Cancer Res. 2007 Jul 15;67(14):6574-81.


Delayed ageing through damage protection by the Arf/p53 pathway.

Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M.

Nature. 2007 Jul 19;448(7151):375-9.


p53 alterations in human cancer: more questions than answers.

Soussi T.

Oncogene. 2007 Apr 2;26(15):2145-56. Review.


Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.

Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TW.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3805-10. Epub 2007 Feb 26. Erratum in: Proc Natl Acad Sci U S A. 2007 May 8;104(19):8196. Liu, Qinghua [added].


DNA damage checkpoints: from initiation to recovery or adaptation.

Bartek J, Lukas J.

Curr Opin Cell Biol. 2007 Apr;19(2):238-45. Epub 2007 Feb 15. Review.


Ten genes for inherited breast cancer.

Walsh T, King MC.

Cancer Cell. 2007 Feb;11(2):103-5.

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