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In vitro reconstitution of gamma-secretase activity using yeast microsomes.

Yagishita S, Futai E, Ishiura S.

Biochem Biophys Res Commun. 2008 Dec 5;377(1):141-5. doi: 10.1016/j.bbrc.2008.09.090. Epub 2008 Oct 1.


Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.

Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10613-8. Epub 2007 Jun 7.


p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.

Dunys J, Kawarai T, Sevalle J, Dolcini V, George-Hyslop PS, Da Costa CA, Checler F.

J Biol Chem. 2007 Apr 6;282(14):10516-25. Epub 2007 Feb 2.


Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

Alves da Costa C, Sunyach C, Pardossi-Piquard R, Sévalle J, Vincent B, Boyer N, Kawarai T, Girardot N, St George-Hyslop P, Checler F.

J Neurosci. 2006 Jun 7;26(23):6377-85.


Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.

Wang R, Zhang YW, Zhang X, Liu R, Zhang X, Hong S, Xia K, Xia J, Zhang Z, Xu H.

FASEB J. 2006 Jun;20(8):1275-7. Epub 2006 Apr 27.


Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.

Wang R, Zhang YW, Sun P, Liu R, Zhang X, Zhang X, Xia K, Xia J, Xu H, Zhang Z.

Mol Cell Biol. 2006 Feb;26(4):1347-54.


Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins.

Dunys J, Kawarai T, Wilk S, St George-Hyslop P, Alves da Costa C, Checler F.

Biochem J. 2006 Mar 1;394(Pt 2):501-9.


A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.

Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.

J Neurochem. 2006 Jan;96(1):118-25. Epub 2005 Nov 21.


Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, Ie L, Koo EH.

J Biol Chem. 2005 Sep 9;280(36):31537-47. Epub 2005 Jul 13.


Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Ring S, D'Adamio L, Shen J, Müller U, St George Hyslop P, Checler F.

Neuron. 2005 May 19;46(4):541-54.


Decrease in NF-kappaB, AP-1 and SP-1 activities in neuronal cells expressing presenilin 2.

Nguyen HN, Lee SY, Hwang DY, Kim YK, Yuk DY, Lee JS, Hong JT.

Neuroreport. 2005 May 12;16(7):731-5.


Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.

Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H.

J Biol Chem. 2005 Apr 29;280(17):17020-6. Epub 2005 Feb 11.


Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J.

J Biol Chem. 2004 Nov 5;279(45):46907-14. Epub 2004 Sep 1.


The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor.

von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U.

J Cell Sci. 2004 Sep 1;117(Pt 19):4435-48.


The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities.

Gu Y, Sanjo N, Chen F, Hasegawa H, Petit A, Ruan X, Li W, Shier C, Kawarai T, Schmitt-Ulms G, Westaway D, St George-Hyslop P, Fraser PE.

J Biol Chem. 2004 Jul 23;279(30):31329-36. Epub 2004 Apr 30.


Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.

Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW.

Biochemistry. 2004 Mar 30;43(12):3555-63.


Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin.

Bergman A, Hansson EM, Pursglove SE, Farmery MR, Lannfelt L, Lendahl U, Lundkvist J, Näslund J.

J Biol Chem. 2004 Apr 16;279(16):16744-53. Epub 2004 Jan 14.


Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells.

Renbaum P, Beeri R, Gabai E, Amiel M, Gal M, Ehrengruber MU, Levy-Lahad E.

Gene. 2003 Oct 30;318:113-24.


C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

Kim HS, Kim EM, Lee JP, Park CH, Kim S, Seo JH, Chang KA, Yu E, Jeong SJ, Chong YH, Suh YH.

FASEB J. 2003 Oct;17(13):1951-3. Epub 2003 Aug 15.


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