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Items: 1 to 20 of 45

1.

The expanded biology of serotonin.

Berger M, Gray JA, Roth BL.

Annu Rev Med. 2009;60:355-66. doi: 10.1146/annurev.med.60.042307.110802. Review.

PMID:
19630576
2.

PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.

Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL.

J Neurosci. 2009 Jun 3;29(22):7124-36. doi: 10.1523/JNEUROSCI.1090-09.2009.

3.

When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.

Su TP, Hayashi T, Vaupel DB.

Sci Signal. 2009 Mar 10;2(61):pe12. doi: 10.1126/scisignal.261pe12. Review.

4.

Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds.

Peters JU, Schnider P, Mattei P, Kansy M.

ChemMedChem. 2009 Apr;4(4):680-6. doi: 10.1002/cmdc.200800411.

PMID:
19266525
5.

The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.

Fontanilla D, Johannessen M, Hajipour AR, Cozzi NV, Jackson MB, Ruoho AE.

Science. 2009 Feb 13;323(5916):934-7. doi: 10.1126/science.1166127.

6.

Protein promiscuity and its implications for biotechnology.

Nobeli I, Favia AD, Thornton JM.

Nat Biotechnol. 2009 Feb;27(2):157-67. doi: 10.1038/nbt1519. Review.

PMID:
19204698
7.

Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery.

Walsh CT, Fischbach MA.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1689-90. doi: 10.1073/pnas.0813405106. Epub 2009 Feb 4. Review. No abstract available.

8.

WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation.

Marona-Lewicka D, Nichols DE.

Behav Pharmacol. 2009 Feb;20(1):114-8. doi: 10.1097/FBP.0b013e3283242f1a.

PMID:
19179855
9.

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore.

Miller JR, Dunham S, Mochalkin I, Banotai C, Bowman M, Buist S, Dunkle B, Hanna D, Harwood HJ, Huband MD, Karnovsky A, Kuhn M, Limberakis C, Liu JY, Mehrens S, Mueller WT, Narasimhan L, Ogden A, Ohren J, Prasad JV, Shelly JA, Skerlos L, Sulavik M, Thomas VH, VanderRoest S, Wang L, Wang Z, Whitton A, Zhu T, Stover CK.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1737-42. doi: 10.1073/pnas.0811275106. Epub 2009 Jan 22.

10.

Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics.

Nigsch F, Bender A, Jenkins JL, Mitchell JB.

J Chem Inf Model. 2008 Dec;48(12):2313-25. doi: 10.1021/ci800079x.

PMID:
19055411
11.

Chemical biology and the limits of reductionism.

Peterson RT.

Nat Chem Biol. 2008 Nov;4(11):635-8. doi: 10.1038/nchembio1108-635. No abstract available.

PMID:
18936741
12.

Drug target identification using side-effect similarity.

Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P.

Science. 2008 Jul 11;321(5886):263-6. doi: 10.1126/science.1158140.

13.

Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

Newman DJ.

J Med Chem. 2008 May 8;51(9):2589-99. doi: 10.1021/jm0704090. Epub 2008 Apr 5. Review. No abstract available.

PMID:
18393402
14.

Quantifying the relationships among drug classes.

Hert J, Keiser MJ, Irwin JJ, Oprea TI, Shoichet BK.

J Chem Inf Model. 2008 Apr;48(4):755-65. doi: 10.1021/ci8000259. Epub 2008 Mar 13.

15.

Computational analysis of ligand relationships within target families.

Bajorath J.

Curr Opin Chem Biol. 2008 Jun;12(3):352-8. doi: 10.1016/j.cbpa.2008.01.044. Epub 2008 Mar 14. Review.

PMID:
18312862
16.

Large-scale chemical dissection of mitochondrial function.

Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK.

Nat Biotechnol. 2008 Mar;26(3):343-51. doi: 10.1038/nbt1387. Epub 2008 Feb 24. Erratum in: Nat Biotechnol. 2008 Jul;26(7):831.

17.

Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor.

Dijkstra D, Stark H, Chazot PL, Shenton FC, Leurs R, Werfel T, Gutzmer R.

J Invest Dermatol. 2008 Jul;128(7):1696-703. doi: 10.1038/sj.jid.5701250. Epub 2008 Jan 31.

18.

Integrating high-content screening and ligand-target prediction to identify mechanism of action.

Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y.

Nat Chem Biol. 2008 Jan;4(1):59-68. Epub 2007 Dec 9.

PMID:
18066055
19.

N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.

Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL.

Neuropsychopharmacology. 2008 Sep;33(10):2303-12. Epub 2007 Dec 5.

20.

Network pharmacology.

Hopkins AL.

Nat Biotechnol. 2007 Oct;25(10):1110-1. No abstract available.

PMID:
17921993

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