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Items: 1 to 20 of 46


Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.

Himanen JP, Goldgur Y, Miao H, Myshkin E, Guo H, Buck M, Nguyen M, Rajashankar KR, Wang B, Nikolov DB.

EMBO Rep. 2009 Jul;10(7):722-8. doi: 10.1038/embor.2009.91. Epub 2009 Jun 12.


Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design.

Bowden TA, Crispin M, Harvey DJ, Aricescu AR, Grimes JM, Jones EY, Stuart DI.

J Virol. 2008 Dec;82(23):11628-36. doi: 10.1128/JVI.01344-08. Epub 2008 Sep 24.


EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line.

Fukai J, Yokote H, Yamanaka R, Arao T, Nishio K, Itakura T.

Mol Cancer Ther. 2008 Sep;7(9):2768-78. doi: 10.1158/1535-7163.MCT-07-2263.


p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping.

Lim YS, McLaughlin T, Sung TC, Santiago A, Lee KF, O'Leary DD.

Neuron. 2008 Sep 11;59(5):746-58. doi: 10.1016/j.neuron.2008.07.032.


Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors.

Noberini R, Koolpe M, Peddibhotla S, Dahl R, Su Y, Cosford ND, Roth GP, Pasquale EB.

J Biol Chem. 2008 Oct 24;283(43):29461-72. doi: 10.1074/jbc.M804103200. Epub 2008 Aug 26.


Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.

Qin H, Shi J, Noberini R, Pasquale EB, Song J.

J Biol Chem. 2008 Oct 24;283(43):29473-84. doi: 10.1074/jbc.M804114200. Epub 2008 Aug 14.


Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Graham SC, Bahar MW, Cooray S, Chen RA, Whalen DM, Abrescia NG, Alderton D, Owens RJ, Stuart DI, Smith GL, Grimes JM.

PLoS Pathog. 2008 Aug 15;4(8):e1000128. doi: 10.1371/journal.ppat.1000128.


Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2.

Bowden TA, Aricescu AR, Gilbert RJ, Grimes JM, Jones EY, Stuart DI.

Nat Struct Mol Biol. 2008 Jun;15(6):567-72. doi: 10.1038/nsmb.1435. Epub 2008 May 18.


Cell-cell signaling via Eph receptors and ephrins.

Himanen JP, Saha N, Nikolov DB.

Curr Opin Cell Biol. 2007 Oct;19(5):534-42. Epub 2007 Oct 24. Review.


Inference of macromolecular assemblies from crystalline state.

Krissinel E, Henrick K.

J Mol Biol. 2007 Sep 21;372(3):774-97. Epub 2007 May 13.


MolProbity: all-atom contacts and structure validation for proteins and nucleic acids.

Davis IW, Leaver-Fay A, Chen VB, Block JN, Kapral GJ, Wang X, Murray LW, Arendall WB 3rd, Snoeyink J, Richardson JS, Richardson DC.

Nucleic Acids Res. 2007 Jul;35(Web Server issue):W375-83. Epub 2007 Apr 22.


Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay.

Pabbisetty KB, Yue X, Li C, Himanen JP, Zhou R, Nikolov DB, Hu L.

Protein Sci. 2007 Mar;16(3):355-61.


A versatile ligation-independent cloning method suitable for high-throughput expression screening applications.

Berrow NS, Alderton D, Sainsbury S, Nettleship J, Assenberg R, Rahman N, Stuart DI, Owens RJ.

Nucleic Acids Res. 2007;35(6):e45. Epub 2007 Feb 22.


Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY.

Nat Neurosci. 2007 Jan;10(1):67-76. Epub 2006 Dec 3.


Eph tyrosine kinase receptor EphA4 is required for the topographic mapping of the corticospinal tract.

Canty AJ, Greferath U, Turnley AM, Murphy M.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15629-34. Epub 2006 Oct 9.


A time- and cost-efficient system for high-level protein production in mammalian cells.

Aricescu AR, Lu W, Jones EY.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1243-50. Epub 2006 Sep 19.


Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity.

Chrencik JE, Brooun A, Kraus ML, Recht MI, Kolatkar AR, Han GW, Seifert JM, Widmer H, Auer M, Kuhn P.

J Biol Chem. 2006 Sep 22;281(38):28185-92. Epub 2006 Jul 25.


Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.

Chrencik JE, Brooun A, Recht MI, Kraus ML, Koolpe M, Kolatkar AR, Bruce RH, Martiny-Baron G, Widmer H, Pasquale EB, Kuhn P.

Structure. 2006 Feb;14(2):321-30.


Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.

Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY.

EMBO J. 2006 Feb 22;25(4):701-12. Epub 2006 Feb 2.


Crystal structure of the ephrin-B1 ectodomain: implications for receptor recognition and signaling.

Nikolov DB, Li C, Barton WA, Himanen JP.

Biochemistry. 2005 Aug 23;44(33):10947-53.


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