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Items: 1 to 20 of 53


Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance.

Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ.

Hepatology. 2009 Jan;49(1):87-96. doi: 10.1002/hep.22578.


Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2.

Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH, Kim KS.

J Biol Chem. 2008 Dec 12;283(50):34896-906. doi: 10.1074/jbc.M804007200. Epub 2008 Oct 16.


Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.

Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D.

Cell. 2008 Oct 3;135(1):61-73. doi: 10.1016/j.cell.2008.07.043.


Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes.

Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR.

Diabetes. 2008 Dec;57(12):3239-46. doi: 10.2337/db08-0872. Epub 2008 Oct 1.


Insulin sensitivity: modulation by nutrients and inflammation.

Schenk S, Saberi M, Olefsky JM.

J Clin Invest. 2008 Sep;118(9):2992-3002. doi: 10.1172/JCI34260. Review.


Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.

Chen Z, Gropler MC, Norris J, Lawrence JC Jr, Harris TE, Finck BN.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1738-44. doi: 10.1161/ATVBAHA.108.171538. Epub 2008 Jul 31.


Inflammatory mechanisms in the regulation of insulin resistance.

Tilg H, Moschen AR.

Mol Med. 2008 Mar-Apr;14(3-4):222-31. doi: 10.2119/2007-00119.Tilg. Review.


Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.

Wunderlich FT, Luedde T, Singer S, Schmidt-Supprian M, Baumgartl J, Schirmacher P, Pasparakis M, Brüning JC.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1297-302. doi: 10.1073/pnas.0707849104. Epub 2008 Jan 23.


Interferon regulatory factors are transcriptional regulators of adipogenesis.

Eguchi J, Yan QW, Schones DE, Kamal M, Hsu CH, Zhang MQ, Crawford GE, Rosen ED.

Cell Metab. 2008 Jan;7(1):86-94. doi: 10.1016/j.cmet.2007.11.002.


JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.

Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M.

Cell Metab. 2007 Nov;6(5):386-97.


Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice.

Ye J, Gao Z, Yin J, He Q.

Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E1118-28. Epub 2007 Jul 31.


Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.

Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ.

Diabetes. 2007 Aug;56(8):1986-98. Epub 2007 May 22. Retraction in: Diabetes. 2016 Apr;65(4):1126-7.


Obesity, inflammation, and insulin resistance.

Shoelson SE, Herrero L, Naaz A.

Gastroenterology. 2007 May;132(6):2169-80. Review.


Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.

Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW.

Circ Res. 2007 Jun 8;100(11):1589-96. Epub 2007 May 3.


Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet.

Otabe S, Yuan X, Fukutani T, Wada N, Hashinaga T, Nakayama H, Hirota N, Kojima M, Yamada K.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E210-8. Epub 2007 Mar 27.


Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance.

Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM.

Nat Med. 2007 Apr;13(4):455-62. Epub 2007 Mar 11.


Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity.

Tenoever BR, Ng SL, Chua MA, McWhirter SM, García-Sastre A, Maniatis T.

Science. 2007 Mar 2;315(5816):1274-8.


Obesity induces a phenotypic switch in adipose tissue macrophage polarization.

Lumeng CN, Bodzin JL, Saltiel AR.

J Clin Invest. 2007 Jan;117(1):175-84.


Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity.

Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR.

Diabetes. 2007 Jan;56(1):16-23.

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